杏仁核5-HT神经环路在失眠障碍及抑郁症共病机制中的功能磁共振成像研究进展

Functional magnetic resonance imaging research progress of the 5-HT neural circuit to amygdala in the multimorbidity of insomnia disorder and depression

失眠障碍(insomnia disorder,ID)及抑郁症是影响患者日常生活及身心健康的常见疾病,ID与抑郁症存在双向关系,二者常共病出现,但具体共病机制不清。杏仁核是情绪环路的关键中枢,五羟色胺(5-hydroxytryptamine,5-HT)通过调控杏仁核活性参与情绪调节,杏仁核5-HT神经环路参与ID及抑郁症。本文阐述了杏仁核及杏仁核5-HT神经环路结构及功能在ID及抑郁症患者的功能磁共振成像(functional magnetic resonance imaging,fMRI)变化,旨在为探究杏仁核5-HT神经环路在ID及抑郁症共病中可能存在的机制提供客观的神经影像学依据。

Insomnia disorder(ID)and depression are common diseases that affect patients'daily life and physical and mental health.There is a bidirectional relationship between ID and depression,and they often present as multimorbidity,but the mechanism is unclear.The amygdala is a key center of the emotional circuit,and 5-hydroxytryptamine(5-HT)participates in emotion regulation by regulating amygdala activity.5-HT neural circuit to amygdala is involved in ID and depression.In this review,we illustrated the changes in the structure and function of the amygdala and 5-HT neural circuit to amygdala in patients with ID and depression through functional magnetic resonance imaging(fMRI),with the aim of providing an objective neuroimaging basis for exploring the possible mechanisms of the 5-HT neural circuit to amygdala in the multimorbidity of ID and depression.