卵圆孔未闭继发偏头痛的脑磁共振成像研究进展

Progress on brain magnetic resonance imaging in migraine secondary to patent foramen ovale

卵圆孔未闭(patent foramen ovale,PFO)是一种先天性心脏结构异常。近年来,越来越多的研究者关注到PFO与偏头痛之间有着密切联系。MRI在神经科学中得到了广泛的应用。结构磁共振成像(structural magnetic resonance imaging,sMRI)可用于研究大脑解剖与结构,对PFO继发偏头痛患者的大脑结构变化进行深入探索。静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)可以无创性检测脑功能活动,为探究PFO继发偏头痛患者的脑功能变化提供了可能。本文从PFO与偏头痛的关系、PFO引起偏头痛的病理生理学机制、MRI在PFO继发偏头痛的应用等方面的研究进展进行综述,以期为临床诊治提供思路,为后续相关领域的研究提供有关参考。

Patent foramen ovale(PFO)is a congenital structural variation of the heart.In recent years,an increasing number of researchers have paid attention to the close relationship between PFO and migraine.MRI has been widely used in neuroscience.Structural magnetic resonance imaging(sMRI)can be used to investigate the anatomy and structure of the brain and further explore the brain structural changes in patients with migraine secondary to PFO.Resting-state functional magnetic resonance imaging(rs-fMRI)offers noninvasive brain functional activity measurement,which provides a possibility to explore the changes of brain function in patients with PFO and migraine.This article reviews the research progress of the correlation between PFO and migraine,the pathophysiological mechanism of migraine caused by PFO,and the application of MRI in migraine secondary to PFO,hoping to provide ideas for clinical diagnosis and treatment,and provide relevant references for follow-up research.