基于数据挖掘和网络药理学探讨马晓昌教授诊疗原发性高血压的用药规律及核心处方的作用机制

The Mechanism of Medication Rules and Core Prescription in the Diagnosis and Treatment of Essential Hypertension by Professor Ma Xiaochang Based on Data Mining and Network Pharmacology

目的:基于数据挖掘及网络药理学方法探讨马晓昌教授辨治原发性高血压的用药规律及相关机制。方法:收集原发性高血压病人的中药处方资料,使用中医传承辅助平台V3.0系统对纳入药物的性味归经及使用频次等进行分析,筛选核心处方。采用网络药理学方法对核心处方进行蛋白-蛋白互作网络、通路和相关靶点的分析。结果:数据挖掘共得到处方323首,涉及中药157味。使用频次居前6位的中药包括葛根、陈皮、茵陈、茯苓、半夏、白术。药物-疾病的共同靶点102个,主要成分包括川陈皮素、槲皮素、柚皮素等57个高频药物。药物的主要靶点包括白细胞介素-6、肿瘤坏死因子、丝氨酸/苏氨酸激酶、白细胞介素-1β等。信号通路涉及流体剪切应力、脂质与动脉粥样硬化通路等。结论:初步得到马晓昌教授治疗原发性高血压的用药特点及核心组方多成分、多靶点、多通路的作用机制。

Objective:To explore the medication rules of Professor Ma Xiaochang for the treatment of essential hypertension by data mining and network pharmacology.Methods:Traditional Chinese medicine prescription data of essential hypertension patients were collected.The natures and flavors normalization and frequency of use of the included drugs were analyzed by the traditional Chinese medicine inheritance auxiliary platform V3.0 system,and the core prescriptions were screened.Network pharmacology was used to analyze the protein-protein interaction network,pathway and related targets of the core prescriptions.Results:A total of 323 prescriptions were obtained by data mining,involving 157 Chinese herbs.The top 6 popular Chinese herbs included Pueraria lobata,Citrus reticulata,Artemisia capillaris,Poria cocos,Pinellia ternata,and Atractylodes macrocephala.There were 102 common targets of drug-disease,and 57 high frequency drugs such as cetin,quercetin and naringin.The main targets of drugs included interleukin-6,tumor necrosis factor,serine/threonine kinase,interleukin-1β.The signaling pathways involved fluid shear stress,lipid and atherosclerotic pathways.Conclusion:The drug characteristics of Professor Ma Xiaochang for the treatment of essential hypertension related the mult-i component,mult-i target and mult-i pathway of the core formula.