黑色素瘤个体化新抗原疫苗的研究进展

Advances in individualized neoantigen vaccines for treatment of melanoma

生产有效的肿瘤疫苗来控制黑色素瘤是近些年新兴的治疗方法之一,随着第二代测序技术的发展,研发个体化新抗原(neoantigen)疫苗已成为肿瘤治疗性疫苗的未来发展方向。文章就用于治疗黑色素瘤的个体化新抗原疫苗的研究进展,使用治疗性疫苗的障碍以及克服这些障碍的有效策略进行概述。

In recent years,the production of effective tumor vaccines to control melanoma has been one of the emerging therapeutic approaches.With the advancement of second-generation sequencing technology,there is now a focus on developing individualized neoantigen vaccines for personalized treatment.This review provides an overview of the progress of research on individualized neoantigen-based vaccines for the treatment of melanoma,the barriers to the use of therapeutic vaccines,and effective strategies to overcome these barriers.