IgA肾病发病机制的相关研究进展

Research advances Progress in the pathogenesis of IgA nephropathy

IgA肾病(IgA nephropathy,IgAN)是全球较为常见的原发性肾小球疾病,也是导致终末期肾病的主要原因之一。随着对疾病研究的深入,近年来诸多研究逐渐阐明了半乳糖缺陷型IgA1的生成、肠道菌群失调、遗传易感性及免疫系统异常在IgAN发病的中的重要作用。为此,本文基于IgAN的“四重打击学说”理论、菌群失调、遗传学以及免疫学机制的相关研究进行综述,为理解这一疾病的多维度影响因素提供了全面的视角。

As the most common primary glomerular disease in the world,IgA nephropathy(IgAN)is one of the major causes of end-stage renal disease(ESRD).With the in-depth studies of IgAN,researchers have gradually clarified the important roles of galactose-deficient IgA1(Gd-IgA1)production,gut microbiome dysbacteriosis,genetic susceptibility and immune system abnormalities in the pathogenesis of IgAN.Therefore this review summarized the latest researches based upon the four-hit hypothesis of IgAN,dysbacteriosis,genetics and immunological mechanism and provides comprehensive perspectives for understanding the multidimensional factors of this disease.