肾小管细胞来源外泌体在肾缺血再灌注损伤中的作用

Role of tubular cell-derived exosomes in renal ischemia reperfusion injury

肾缺血再灌注损伤是指肾组织短暂缺血后,恢复血供导致肾脏损伤程度加重的一种病理生理现象。研究发现肾小管细胞来源外泌体通过抗炎、抗氧化、抑制细胞凋亡、促进组织再生和激活自噬等作用减轻肾缺血再灌注损伤。本研究就肾小管细胞来源外泌体对肾缺血再灌注损伤的保护作用作一简要综述,以期为肾缺血再灌注损伤的临床诊治与早期预防提供理论依据。

Renal ischemia reperfusion injury refers to a pathophysiological phenomenon that aggravates the degree of renal injury due to the restoration of blood supply after transient ischemia of renal tissue.It has been found that renal tubular cell-derived exosomes alleviate renal ischemia reperfusion injury through anti-inflammatory,antioxidant,inhibition of apoptosis,promotion of tissue regeneration and activation of autophagy.This review will discuss the protective effect of tubular cell-derived exosomes on renal ischemia reperfusion injury,in order to provide a theoretical basis for the clinical diagnosis,treatment and early prevention of renal ischemia reperfusion injury.