心率变异性频域和时域相关指标与冠心病患者心血管事件的关系

Relationships between Frequency Domain and Time Domain Related Indexes of Heart Rate Variability and Cardiovascular Events in Patients with Coronary Heart Disease

目的探讨冠心病患者心率变异性频域和时域相关指标与心血管事件的关系。方法纳入116例冠心病患者为研究对象,记录心率变异性频域和时域指标。随访1年,将患者分为心血管事件组和无心血管事件组,分析心率变异性频域和时域指标与心血管事件的关系。结果116例冠心病患者中发生心血管事件74例(63.79%);心血管事件组年龄、TG水平高于非心血管事件组,LF、LF/HF、SDNN、RMSSD、PNN50低于非心血管事件组(P均<0.05);LF、LF/HF、SDNN、RMSSD、PNN50与冠心病患者发生心血管事件呈负相关(r<0,P<0.05);年龄增大、TG升高及LF、LF/HF、SDNN、RMSSD、PNN50降低是冠心病患者发生心血管事件的危险因素(OR>1,P<0.05);LF、LF/HF、SDNN、RMSSD、PNN50对冠心病患者发生心血管事件具有一定预测价值(AUC=0.780、0.949、0.749、0.802、0.781,P均<0.05)。结论冠心病患者心率变异性频域和时域相关指标与冠心病患者心血管事件的发生密切相关,LF、LF/HF、SDNN、RMSSD、PNN50低可能增加发生心血管事件风险。

Objective To explore the relationships between heart rate variability in frequency domain and time domain and cardiovascular events in patients with coronary heart disease.Methods 116 patients with coronary heart disease were included as the research objects,and the frequency domain and time domain indexes of heart rate variability were recorded.After a one-year follow-up,the patients were divided into cardiovascular event group and non-cardiovascular event group,and the relationships between frequency domain and time domain indexes of heart rate variability and cardiovascular events were analyzed.Results Among 116 patients with coronary heart disease,74 cases(63.79%)had cardiovascular events.The age and TG levels in cardiovascular event group were higher than those in non-cardiovascular event group,while LF,LF/HF,SDNN,RMSSD and PNN50 were lower than those in non-cardiovascular event group(P<0.05).The results showed that LF,LF/HF,SDNN,RMSSD and PNN50 were negatively correlated with cardiovascular events in patients with coronary heart disease(r<0,P<0.05).The increased of age,TG,and the decreased of LF,LF/HF,SDNN,RMSSD and PNN50 were risk factors for cardiovascular events in patients with coronary heart disease(OR>1,P<0.05).LF,LF/HF,SDNN,RMSSD and PNN50 had certain predictive value for cardiovascular events in patients with coronary heart disease(AUC=0.780,0.949,0.749,0.802,0.781,P<0.05).Conclusion The correlation indexes of heart rate variability in frequency domain and time domain are closely related to the occurrence of cardiovascular events in patients with coronary heart disease.Low LF,LF/HF,SDNN,RMSSD and PNN50 may increase the risk of cardiovascular events.