结直肠癌术后感染与肠道微生态及肠道屏障功能的关系

Relationship Between Postoperative Infection of Colorectal Cancer,Intestinal Microecology and Intestinal Bar-rier Function

目的:探讨结直肠癌术后感染患者血清核因子κB(NF-κB)、白细胞介素-6(IL-6)表达与肠道微生态及肠道屏障功能的关系。方法:回顾性分析2020年10月至2023年10月我院收治的64例结直肠癌术后患者临床资料,根据是否出现术后感染分为感染组23例和未感染组41例。比较2组患者肠道菌群失调情况,血清NF-κB、IL-6水平及肠道微生态和肠道屏障功能指标,感染患者NF-κB、IL-6表达与肠道微生态及肠道屏障功能指标的关系行Pearson相关性分析。结果:感染组患者肠道菌群失调率较未感染组高,差异有统计学意义(P<0.05)。感染组患者血清NF-κB、IL-6水平、血浆D-乳酸、DAO水平、L/M值、大肠埃希菌菌落数量均高于未感染组,双歧杆菌菌落数量低于未感染组,差异均有统计学意义(P<0.05)。感染组患者血清NF-κB、IL-6水平与大肠埃希菌菌落数量、D-乳酸、DAO水平、L/M值呈正相关,与双歧杆菌菌落数量呈负相关(P<0.05)。结论:结直肠癌术后感染患者肠道菌群失调率较高,血清NF-kB、IL-6水平较未感染患者显著升高,且常出现肠道菌群分布失衡和肠道屏障功能受损。此外NF-kB、IL-6的表达与感染患者肠道微生态及肠道屏障功能指标相关。

Objective To investigate the relationship between the serum expression of nuclear factor-κB(NF-κB)and interleukin-6(IL-6),intestinal microecology and intestinal barrier function in patients with postoperative infection of colorectal cancer.Methods Clinical data of 64 patients with colorectal cancer treated in our hospital from October 2020 to October 2023 were retrospectively analyzed,and they were di-vided into infected group(23 cases)and uninfected group(41 cases)according to postoperative infection.The intestinal flora imbalance,serum levels of NF-κB and IL-6,intestinal microecology and intestinal barri-er function indexes were compared between the two groups.The relationship between the expression of NF-κB and IL-6,intestinal microecology and intestinal barrier function indexes in patients with postopera-tive infection was analyzed by Pearson correlation analysis.Results The rate of intestinal flora disorder in the infected group was higher than that in the uninfected group,and the difference was statistically sig-nificant(P<0.05).Serum levels of NF-κB and IL-6,plasma levels of D-lactic acid and DAO,L/M value and the number of Escherichia coli colonies in the infected group were higher than those in the uninfected group,while the number of bifidobacterium colonies was lower than that in the uninfected group,with sta-tistical significance(P<0.05).Serum levels of NF-κB and IL-6 in the infected group were positively cor-related with the number of Escherichia coli colonies,levels of D-lactic acid and DAO,and L/M value,and negatively correlated with the number of bifidobacterium colonies(P<0.05).Conclusion Patients with postoperative infection of colorectal cancer have a higher rate of intestinal flora imbalance,and the ser-um levels of NF-κB and IL-6 are significantly higher than those of the uninfected group,with distribution imbalance of intestinal flora and intestinal barrier dysfunction.In addition,the expression of NF-κB and IL-6 was correlated with intestinal microecology and intestinal barrier function indexes of patients with postoperative infection.