舍曲林联合认知行为治疗对青少年抑郁症患者的疗效

Effect of Sertraline Tablets Combined with Cognitive Behavior Therapy on Adolescent Depression

目的 探讨在青少年抑郁症患者治疗中,选择舍曲林联合认知行为疗法的价值,并分析该方案对患者认知、睡眠等多项指标的影响。方法 以EXCEL表格统计2021年1月~2022年12月确诊为抑郁症的110例青少年患者,以随机数字表法分2组,一组接受盐酸舍曲林治疗(对照),一组接受盐酸舍曲林+认知行为疗法实施治疗(观察)。统计治疗两组患者的临床疗效,并就治疗前后认知功能、睡眠状态、自杀意念、抑郁评分进行对比。结果 较对照而言,观察组55例患者治疗后统计的临床疗效升高(P<0.05);观察组统计的治疗后1周、2周、6周蒙特利尔认知评估量表评分升高(P<0.05);观察组统计的治疗后1周、2周、6周匹兹堡睡眠质量指数评分降低(P<0.05);观察组统计的治疗后1周、2周、6周自杀态度测评量表评分升高(P<0.05);观察组汉密尔顿抑郁量表-17评分低于对照组(P<0.05)。结论 在青少年抑郁症治疗中选择舍曲林联合认知行为疗法的方案可更好地改善其认知功能,减轻抑郁症状对患者睡眠质量的影响,避免其产生自身意念影响自身安全及社会安全。

Objective Explore the value of combining Shequlin tablets with cognitive-behavioral therapy in the treatment of adolescent depression patients,and analyze the impact of this program on multiple indicators such as cognition and sleep.Methods A total of 110 adolescent patients diagnosed with depression from January 2021to December 2022 were randomly divided into two groups using an Excel spreadsheet.One group received treatment with sertraline hydrochloride(control),while the other group received treatment with sertraline hydrochloride and cognitive-behavioral therapy(observation).Compare the clinical efficacy of treating two groups of patients and assess their cognitive function,sleep status,suicidal ideation,and depression scores before and after treatment.Results Compared with the control group,the clinical efficacy of the observation group of 55 patients increased after treatment(P<0.05).The observation group showed an increase in the scores of the Montreal Cognitive Assessment Scale at 1,2,and 6 weeks after treatment(P<0.05).The observation group showed a decrease in Pittsburgh Sleep Quality Index scores at 1,2,and 6 weeks after treatment(P<0.05).The suicide attitude assessment scores of the observation group increased significantly at 1 week,2 weeks,and 6 weeks after treatment(P<0.05).The Hamilton Depression Scale-17 score in the observation group was lower than that in the control group(P<0.05).Conclusion Choosing the combination of Shequlin tablets and cognitive-behavioral therapy in the treatment of adolescent depression can better improve their cognitive function,alleviate the impact of depressive symptoms on patients' sleep quality,and avoid their own thoughts affecting their own safety and social security.