帕罗西汀对合并失眠的冠心病患者睡眠及情绪的影响

Effects of paroxetine on sleep and mood in patients with coronary heart disease complicated with insomnia

目的 探讨冠心病合并失眠患者在治疗中,采用帕罗西汀的价值。方法 以EXCEL表格统计2021年3月~2023年3月本院收治的200例冠心病合并失眠的患者研究,以序贯平衡法分组,一组接受心理干预(纳入对照组),二组在一组基础上接受帕罗西汀治疗(纳入观察组)。对比200例患者的临床疗效,并分析干预后患者睡眠质量、心理状态变化。结果 观察组100例患者经帕罗西汀治疗后临床疗效高于对照组(P<0.05);观察组睡眠状况自评量表(Self-Rating Scale of Sleep,SRSS)评分低于对照组(P<0.05);观察组汉密顿抑郁量表-17(Hamilton Depression Scale-17,HAMD-17)、汉密顿焦虑量表(Hamilton Anxiety Scale,HAMA)评分低于对照组(P<0.05)。结论在冠心病合并失眠患者治疗中选择帕罗西汀可改善其睡眠质量及心理状态,提高整体治疗效果。

Objective To explore the value of Paroxetine in the treatment of coronary heart disease with insomnia.Methods 200 patients with coronary heart disease and insomnia admitted to our hospital from March 2021 to March 2023 were recruited and divided into two groups by sequential balance method.The control group received psychological intervention(included in the control group),and the observation group received Paroxetine treatment(included in the observation group)on the basis of the first group.Compare the clinical efficacy of 200 patients and analyze the changes in their sleep quality and psychological state after intervention.Results The clinical efficacy of 100 patients in the observation group after Paroxetine treatment was higher than that in the control group(P<0.05).The Self Rating Scale of Sleep(SRSS)score in the observation group was lower than that in the control group(P<0.05).The Hamilton Depression Scale-17(HAMD-17) and Hamilton Anxiety Scale(HAMA)scores in the observation group were lower than those in the control group(P<0.05).Conclusion The choice of Paroxetine in the treatment of coronary heart disease patients with insomnia can improve their sleep quality and psychological state,and improve the overall treatment effect,which is worth learning and implementing.