摘要
Nanovaccines have gathered significant attention for their potential to elicit tumor-specific immunological responses.Despite notable progress in tumor immunotherapy,nanovaccines still encounter considerable challenges such as low delivery efficiency,limited targeting ability,and suboptimal efficacy.With an aim of addressing these issues,engineering customized nanovaccines through modification or functionalization has emerged as a promising approach.These tailored nanovaccines not only enhance antigen presentation,but also effectively modulate immunosuppression within the tumor microenvironment.Specifically,they are distinguished by their diverse sizes,shapes,charges,structures,and unique physicochemical properties,along with targeting ligands.These features of nanovaccines facilitate lymph node accumulation and activation/regulation of immune cells.This overview of bespoke nanovaccines underscores their potential in both prophylactic and therapeutic applications,offering insights into their future development and role in cancer immunotherapy.
基金
financially supported by the National Key R&D Program of China(Grant No.2022YFB3808000/2022YFB3808001,Grant No.2021YFC2400600/2021 YFC2400604)
the Medical Innovation Project of Science and Technology Program of Fujian Provincial Health Commission(Grant No.2021CXA006)
the Project for High-Level Talent Innovation and Entrepreneurship of Quanzhou(Grant No.2022C016R)
the Key Program of Qingyuan Innovation Laboratory(Grant No.00221002).
