复杂性先天性心脏病神经功能障碍相关危险因素的研究进展

Progress in the study of risk factors associated with neurodevelopmental disorders in complex congenital heart disease

先天性心脏病(congenital heart disease, CHD)是最常见的出生缺陷, 近年来其神经发育障碍(neurodevelopmental disorder, NDD)已逐渐得到重视, 其中复杂性先天性心脏病(complex congenital heart disease, CCHD)发生神经发育障碍更为常见, 相关危险因素的研究正逐步深入。CCHD神经发育障碍的危险因素复杂多样, 有协同、累积效应, 按时间阶段可分为术前、手术相关和术后3方面, 涉及遗传、血流动力学紊乱、体外循环、护理、家庭社会因素等各个方面。本文结合最新的国内外研究, 尝试对CCHD神经发育障碍的危险因素进行综述。

Congenital heart disease(CHD)is the most common birth defect,and in recent years,its neurodevelopmental disorder(NDD)has been gradually emphasized,among which neurodevelopmental disorder in complex congenital heart disease(CCHD)is more common,and the research on related risk factors is gradually deepening.The risk factors of CCHD neurodevelopmental disorder are complex and diversified,with synergistic and cumulative effects,which can be classified into preoperative,surgical-related and postoperative according to the time period,and involve various aspects such as genetics,hemodynamic disorders,extracorporeal circulation,nursing care,and family and social factors.In this paper,we try to review the risk factors of neurodevelopmental disorders in CCHD by combining the latest domestic and international studies.