乳酸菌在眼科的应用潜力

Application Potential of Lactic Acid Bacteria in Ophthalmology

乳酸菌具有营养、抑菌、免疫调节等生物学功能,在食品、农牧业、工业、医药等领域中发挥重要作用。目前乳酸菌在临床应用研究中,关注焦点集中于胃肠道疾病、泌尿道感染、慢性鼻炎、抗肿瘤等,却鲜有介绍乳酸菌在眼部应用的研究进展。乳酸菌治疗眼病的作用机制除了通过调节炎症外,还可通过直接作用或间接作用机制治疗眼病。本文通过回顾乳酸菌在眼表疾病、真菌性角膜炎、晶状体和视网膜等疾病的应用,按乳酸菌株及其相关机制进行归纳和总结,比较不同的乳酸菌株治疗眼科疾病的差异,总结了乳酸菌在眼部研究中的体外、体内及临床证据,使用乳酸菌治疗具有较高安全性。对眼科疾病的应用展现出显著的创新性和临床意义,拓宽了乳酸菌在眼科的应用范围,为未来的临床治疗提供了新的思路。

Lactic acid bacteria(LAB)have biological functions such as nutrition,bacteriostasis and immune regulation,which play important roles in the fields of food,agriculture and animal husbandry,industry,medicine and so on.At present,in the clinical application research of LAB,the focus of attention is on gastrointestinal diseases,urinary tract infections,allergic rhinitis,anti-tumor,etc.,but there are few introductions to the research progress of LAB in ocular application.In addition to regulating inflammation,the mechanism of action of lactic acid bacteria in the treatment of eye diseases is also affected by different mechanisms,which can be divided into direct and indirect effects.This article reviews the application of lactic acid bacteria in ocular surface diseases,fungal keratitis,lens and retinal diseases,summarizes and summarizes lactic acid strains and their related mechanisms,compares the differences of different lactic acid strains in the treatment of ophthalmic diseases.The in vitro,in vivo and clinical evidence of lactic acid bacteria in ophthalmic research are summarized,and the use of lactic acid bacteria in the treatment has high safety.The application of ophthalmic diseases has shown significant innovation and clinical significance,broadened the application scope of lactic acid bacteria in ophthalmology,and provided new ideas for future clinical treatment.