Sonic Hedgehog信号通路参与椎间盘退变的研究进展

Research Progress of Sonic Hedgehog Signaling Pathway Involved in Intervertebral Disc Degeneration

随着社会老龄化的加剧,越来越多的患者受到腰背痛的困扰,给患者和社会带来负担。椎间盘退变(IVDD)是导致慢性腰背痛的主要原因,阐明IVDD的致病机制对解决当前所面临的健康问题具有重要意义。近年来,关于Sonic Hedgehog(Shh)通路在IVDD中的研究报道不断出现,Shh信号通路在椎间盘的形成和出生后维持中具有重要作用,并且该通路的表达变化伴随着椎间盘的年龄相关性退行性改变,靶向Shh信号通路可能在IVDD治疗中具有重要意义。本研究对Shh通路在IVDD中的研究进展进行总结,试图探索该信号通路与IVDD的各种已知病理之间的可能联系,并对未来的研究内容进行展望,以期为探究IVDD的有效治疗方式及预防手段提供参考。

With the intensification of aging society,more and more patients are troubled by low back pain,which brings burden to patients and society.Intervertebral disc degeneration(IVDD)is the main cause of chronic low back pain.Clarifying the pathogenic mechanism of IVDD is of great significance to solve the current health problems.In recent years,there have been a lot of reports on the role of the Sonic Hedgehog(Shh)pathway in IVDD.Shh signaling pathway plays an important role in the formation and postnatal maintenance of intervertebral disc,and the expression change of this pathway is accompanied by age-related degenerative changes of intervertebral disc.Targeting the Shh signaling pathway may have important implications in IVDD treatment.This review summarizes the research progress of Shh signaling pathway in IVDD,attempts to explore the possible relationship between this signaling pathway and various known pathologies of IVDD,and looks forward to future research content,in order to provide reference for exploring effective treatment and prevention methods of IVDD.