Hippo信号通路在缺血性脑卒中的作用及相关研究进展

The Role of Hippo Signaling Pathway in Ischemic Stroke and Related Rresearch Progress

缺血性脑卒中(IS)是一种常见的中枢神经系统疾病。Hippo信号通路可通过参与脑损伤相关的神经再生、细胞凋亡、炎症反应、氧化应激等多种病理生理过程影响IS的发生发展及预后。本文就Hippo信号通路在IS中的作用机制及通路间互作进行系统性总结,以期为今后临床上治疗IS提供更多的选择及思路。

Ischemic stroke(IS)is a common disease of the central nervous system.Hippo signaling pathway can affect the occurrence,development and prognosis of IS by participating in various pathophysiological processes related to brain injury,such as nerve regeneration,apoptosis,inflammation and oxidative stress.In this paper,the mechanism of action of Hippo signaling pathway in IS and the interaction between pathways are systematically summarized,in order to provide more options and ideas for the future clinical treatment of IS.