依达拉奉右莰醇联合丁苯酞治疗急性脑梗死的临床效果

The Clinical Effect of Edaravone Combined with Dexamethasone and Bu⁃tylphthalide in the Treatment of Acute Cerebral Infarction

目的研究依达拉奉右莰醇单独使用及联合丁苯酞治疗急性脑梗死的疗效差异。方法非随机选取2022年7月—2023年12月于徐州市铜山区中医院就诊的86例急性脑梗死患者为研究对象,按治疗方法不同分为对照组(43例)与观察组(43例)。对照组给予依达拉奉右莰醇注射液治疗,观察组采用依达拉奉右莰醇注射液联合丁苯酞注射液治疗。比较两组治疗效果。结果观察组患者血清超敏C反应蛋白、S100钙结合蛋白B、同型半胱氨酸分别为(8.56±2.86)mg/L、(0.69±0.52)ng/mL、(8.32±3.57)µmol/L低于对照组的(12.12±2.92)mg/L、(0.97±0.61)ng/mL、(12.96±3.48)µmol/L,差异有统计学意义(t=-5.711、-2.291、-6.103,P均<0.05);观察组美国国立卫生研究院卒中量表评分为(7.65±5.52)分,低于对照组的(9.95±2.97)分,差异有统计学意义(t=-3.872,P<0.05);观察组独立生活能力量表评分及治疗总有效率高于对照组,差异有统计学意义(P均<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论依达拉奉右莰醇联合丁苯酞治疗急性脑梗死可提高治疗效果,且安全性较高。

Objective To investigate the effect of edaravone dextrocamphorol alone and combined with butylphthalein in the curative effect of acute cerebral infarction.Methods Eighty-six patients with acute cerebral infarction who vis-ited the department of neurology in Xuzhou Tongshan District Hospital of Traditional Chinese Medicine from July 2022 to December 2023 were non-randomly selected as study objects.According to the different treatment methods,they were divided into control group(forty-three cases)and observation group(forty-three cases).Edaravone Dexacam-phor was used in the control group alone,while the observation group was treated with Edaravone Dexacamphor com-bined with Butylphthalein.Compare the efficacy between two groups of patients.Results The serum high-sensitivity C-reactive protein,S100 calcium binding protein B and homocysteine in observation group were(8.56±2.86)mg/L,(0.69±0.52)ng/mL,(8.32±3.57)μmol/L,which were lower than those in control group(12.12±2.92)mg/L,(0.97±0.61)ng/mL,(12.96±3.48)μmol/L,the differences were statistically significant(t=-5.711,-2.291,-6.103,all P<0.05);The National Institutes of Health Stroke Scale score of the observation group was 7.65±5.52,lower than 9.95±2.97 of the control group,and the difference was statistically significant(t=-3.872,P<0.05);The Bathel Index score and total ef-fective rate were higher than those of control group,the differences were statistically significant(both P<0.05);There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Con-clusion The combined application of two drugs in the treatment of acute cerebral infarction can improve the therapeu-tic effect of patients,improve the therapeutic efficiency and still have safety.