小儿硫酸亚铁糖浆与右旋糖酐铁口服液治疗小儿营养性缺铁性贫血的有效性及安全性比较

Comparison of the Effectiveness and Safety of Pediatric Ferrous Sulfate Syrup and Dextran Iron oral Solution in the Treatment of Nutritional Iron Deficiency Anemia in Children

目的比较营养性缺铁性贫血患儿分别采用小儿硫酸亚铁糖浆、右旋糖酐铁口服液治疗的有效性及安全性。方法非随机选取2020年8月—2023年2月就诊于兰州市西固区妇幼保健院的80例营养性缺铁性贫血患儿作为研究对象,根据治疗方式的不同分为两组,每组40例。观察组与对照组分别服用右旋糖酐铁口服液与小儿硫酸亚铁糖浆。对两组患儿临床疗效、细胞因子水平、血常规、铁代谢指标及不良反应发生率进行比较。结果治疗后,观察组治疗总有效率为95.00%(38/40)较对照组75.00%(30/40)高,差异有统计学意义(χ^(2)=6.275,P<0.05);观察组血清铁蛋白水平、平均红细胞体积、平均红细胞血红蛋白含量、平均红细胞血红蛋白浓度均较对照组高,差异有统计学意义(P均<0.05);观察组患儿细胞因子水平中白介素2水平较对照组高,白介素6水平、白介素10水平均较对照组低,差异有统计学意义(P均<0.05);观察组不良反应总发生率为5.00%(2/40)较对照组22.50%(9/40)低,差异有统计学意义(χ^(2)=5.165,P<0.05)。结论与小儿硫酸亚铁糖浆相比,右旋糖酐铁口服液可更有效地改善患儿的贫血症状、铁代谢指标及血常规指标,促进细胞炎性因子下调,且用药安全性较高。

Objective To compare the effectiveness and safety of ferrous sulfate syrup and iron dextran oral solution in the treatment of children with nutritional iron deficiency anemia.Methods A total of eighty children with nutritional iron deficiency anemia who were treated in Xigu District Maternal and Child Health Hospital of Lanzhou City from Au-gust 2020 to February 2023 were non-randomly selected as the research objects,and divided into two groups accord-ing to different treatment methods,with forty cases in each group.The observation group and the control group were treated with iron dextran oral liquid and pediatric ferrous sulfate syrup,respectively.The clinical efficacy,cytokine levels,blood routine,iron metabolism indexes and incidence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the observation group was 95.00%(38/40)higher than that of the control group 75.00%(30/40),and the difference was statistically significant(χ^(2)=6.275,P<0.05).The serum fer-ritin level,mean corpuscular volume,mean corpuscular hemoglobin content and mean corpuscular hemoglobin concen-tration in the observation group were higher than those in the control group,and the differences were statistically sig-nificant(P<0.05).The level of interleukin 2 in the cytokine level of the observation group was higher than that of the control group,and the levels of interleukin 6 and interleukin 10 were lower than those of the control group,and the dif-ferences were statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was 5.00%(2/40)lower than that in the control group 22.50%(9/40),and the difference was statistically significant(χ^(2)=5.165,P<0.05).Conclusion Compared with children's ferrous sulfate syrup,dextran oral liquid can improve anemia symptoms,iron metabolism indexes and blood routine indexes more effectively,regulate the cytokine level and have higher drug safety.