甲地孕酮通过调节凋亡因子Bcl-2和Bax的表达治疗宫颈癌的研究

Study on megestrol in treating cervical cancer by regulating apoptosis factors B cell leukemia iymphoma-2 and B cell leukemia iymphoma-2 associated X protein expressions

目的探讨甲地孕酮通过调节凋亡因子B淋巴细胞瘤-2基因(Bcl-2)和Bcl-2相关X基因(Bax)的表达治疗宫颈癌的作用。方法选取2021年1月至2023年12月皖西卫生职业学院附属医院收治的100例宫颈癌患者作为研究对象,进行前瞻性研究,按照入院后的电子编号分为研究组和对照组,每组50例。对照组采用紫杉醇与顺铂化疗方案治疗,研究组在对照组基础上加用甲地孕酮治疗。比较两组临床疗效、生活质量、Bcl-2和Bax表达水平、不良反应发生情况。结果研究组治疗总有效率高于对照组(P<0.05)。研究组卡氏功能状态评分标准(KPS)评分、食欲改善评分、体重增加及平均能量摄取情况均高于对照组(P<0.05)。治疗前,两组Bcl-2和Bax表达水平比较,差异无统计学意义(P>0.05);治疗后,两组Bcl-2和Bax表达水平均降低,且研究组均低于对照组(P<0.05)。研究组不良反应总发生率低于对照组(P<0.05)。结论宫颈癌患者采用甲地孕酮联合紫杉醇与顺铂化疗方案治疗,可通过下调Bcl-2和Bax表达水平提高患者的治疗效果和生活质量,且不会增加不良反应的发生。

Objective To explore the effect of megestrol in treating cervical cancer by regulating apoptosis factors B cell leukemia iymphoma-2(Bcl-2)and B cell leukemia iymphoma-2 associated X protein(Bax)expressions.Methods A total of 100 cases of cervical cancer patients admitted to the Anhui West Health Vocational College Affiliated Hospital from January 2021 to December 2023 were selected as the research objects for prospective study.According to the electronic numbers after admission,they were divided into study group and control group,with 50 cases in each group.The control group was treated with paclitaxel and cisplatin chemotherapy,and the study group was treated with megestrol based on the control group.The clinical efficacy,quality of life,expression levels of Bcl-2 and Bax and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of study group was higher than that of control group(P<0.05).The scores of Karnofsky performance status(KPS),appetite improvement score,weight gain and average energy intake of the study group were all higher than those of the control group(P<0.05).Before treatment,there was no significant difference in the expression levels of Bcl-2 and Bax between the two groups(P>0.05).After treatment,the expression levels of Bcl-2 and Bax were all decreased in both groups,and the study group were lower than the control group(P<0.05).The total incidence of adverse reactions in the study group was lower than that in the control group(P<0.05).Conclusions Megestrol combined with paclitaxel and cisplatin in the treatment of cervical cancer patients can improve the therapeutic effect and quality of life of patients by down-regulation of the expression levels of Bcl-2 and Bax,without increasing the occurrence of adverse reactions.