丙戊酸钠治疗癫痫对患者神经功能、血清神经元特异烯醇化酶的影响

Effects of sodium valproate on neurological function and serum neuron-specific enolase in patients with epilepsy

目的 分析丙戊酸钠治疗癫痫的效果,并针对药物作用对患者神经功能、血清神经元特异烯醇化酶的影响进行分析.方法 选取了本院收治的80例癫痫患者(时间区间:2021年1月-2024年1月),作为本次的研究对象.分组方式是按照患者姓氏首字母次序,将80名研究对象均分成两组.分别设定为对照组、观察组.对照组患者予以卡马西平片治疗,观察组采用丙戊酸钠片治疗.结果 治疗24周后,观察组治疗总有效率显著高于对照组,神经功能缺损评分、血清神经元特异烯醇化酶水平显著低于对照组(P<0.05);治疗后组间不良反应发生率无显著差异(P>0.05).结论 对癫痫患者使用丙戊酸钠片治疗,对于改善患者的神经功能、调节血清神经元特异烯醇化酶水平作用显著,可提升整体疗效,具有较好的应用效果.

Objective To analyze the effect of sodium valproate in the treatment of epilepsy,and to analyze the effect of the drug on the nerve function and serum neuron specific enolase.Methods 80 patients with epilepsy admitted to our hospital(time interval:January 2021 to January 2024)were selected as the objects of this study.The study subjects were divided into two groups according to the first alphabetical order of the patients'last names.They were set as control group and observation group respectively.Control group was treated with carbamazepine tablets,observation group was treated with sodium valproate tablets.Results After 24 weeks of treatment,the effective rate of treatment in observation group was significantly higher,the score of nerve function deficit and the level of serum neuron specific enolase were significantly lower(P<0.05);there was no significant difference in the incidence of adverse reactions between groups afer treatment(P>0.05).Conclusion The use of sodium valproate tablets in the treatment of epilepsy patients has a significant effect on improving the neurological function of patients,regulating the level of serum neuron specific enolase,and improving the overall curative effect.