替奈普酶静脉溶栓对急性ST段抬高型心肌梗死患者治疗效果及心功能的影响

Effect of Teneplase Intravenous Thrombolysis on Therapeutic Effect and Cardiac Function in Patients with Acute ST Segment Elevation Myocardial Infarction

目的分析替奈普酶静脉溶栓对急性ST段抬高型心肌梗死患者的作用。方法选取2019年7月至2022年7月我院实施静脉溶栓桥接PCI治疗的75例急性ST段抬高型心肌梗死者,并依据患者的治疗方式差异将其分入观察组(38例)和对照组(37例),对照组患者采用瑞替普酶静脉溶栓治疗,观察组患者应用替奈普酶静脉溶栓治疗。比较两组急性ST段抬高型心肌梗死治疗总有效率、心肌损伤标志物水平(指标包括:血清N末端脑钠肽前体、心肌钙蛋白、肌酸激酶同工酶)改善情况、左心室舒张末直径等心功能、不良反应发生率及病死率。结果观察组急性ST段抬高型心肌梗死治疗总有效率为94.74%,对照组为91.89%,观察组急性ST段抬高型心肌梗死治疗总有效率略优于对照组(P<0.05)。两组急性ST段抬高型心肌梗死患者治疗前血清N末端脑钠肽前体、心肌钙蛋白、肌酸激酶同工酶等心肌损伤标志物水平相比均无明显差异(P>0.05),治疗后两组心肌损伤标志物水平比治疗前均有显著改善(P<0.05),且观察组急性ST段抬高型心肌梗死患者改善水平略优于对照组(P<0.05)。治疗后两组左心室舒张末直径等心功能水平相比均无明显差异(P>0.05)。观察组急性ST段抬高型心肌梗死患者不良反应发生率及病死率低于对照组(P<0.05)。结论替奈普酶静脉溶栓能有效提高急性ST段抬高型心肌梗死的治疗效果,减少并发症发生,具有非常重要的临床价值。

Objective To analyze the effect of teneplase intravenous thrombolysis on patients with acute ST segment elevation myocardial infarction.Methods Seventy-five patients with myocardial infarction who underwent intravenous thrombolytic bridging PCI in our hospital from July 2019 to July 2022 were selected,and divided into observation group(38 cases)and control group(37 cases)according to the differences in treatment methods.The control group received intravenous thrombolytic therapy with reteplase,and the observation group received intravenous thrombolytic therapy with teneplase.The total effective rate,the improvement of myocardial injury markers(including serum N-terminal brain natriuretic peptide precursor,cardiac calcin and creatine kinase isoenzyme),the left ventricular end-diastolic diameter and the incidence of adverse reactions were compared between the two groups.Results The total effective rate was 94.74%in the observation group and 91.89% in the control group.The total effective rate in the observation group was slightly better than that in the control group(P<0.05).There were no significant differences in serum N-terminal brain natriuretic peptide precursor,myocardial calcin,creatine kinase isoenzyme and other myocardial injury markers between the two groups before treatment(P>0.05);After treatment,the levels of myocardial injury markers in both groups showed significant improvement compared to before treatment(P<0.05).The improvement level of patients with acute ST-segment elevation myocardial infarction in observation group was slightly better than that in control group(P<0.05).There were no significant differences in left ventricular end-diastolic diameter and cardiac function between the two groups after treatment(P>0.05).The incidence of adverse reactions and mortality rate in patients with acute ST segment elevation myocardial infarction in observation group was lower than that in control group(P<0.05).Conclusions Teneplase intravenous thrombolysis can effectively improve the treatment effect of acute ST segment elevation myocardial infarction and reduce complications,which has very important clinical value.