吲哚衍生物的抗鲍曼不动杆菌活性研究进展

Recent Developments of Indole Derivatives with anti-Acinetobacter baumannii Potential

鲍曼不动杆菌是一种条件致病性革兰阴性菌,因其能引起院内严重全身感染而严重威胁人类健康。现有的抗鲍曼不动杆菌药物在治疗药敏型鲍曼不动杆菌引起的感染方面发挥着关键作用,但对耐多药和全耐药鲍曼不动菌引起的感染目前可供选择的药物屈指可数。因此,迫切需要开发新型抗鲍曼不动菌药物。吲哚可作用于细菌的各种靶标,对各种鲍曼不动杆菌感染具有潜在的治疗作用,是开发新型抗鲍曼不动菌药物的优良药效团。本文综述了2020年至今所开发的具有抗鲍曼不动杆菌潜力的吲哚衍生物的最新研究进展,为未来发现新的候选药物提供理论支持。

Acinetobacter baumannii,a conditionally pathogenic Gram-negative pathogen,is infamous for its capacity to cause hospital-acquired severe systemic infections.There is an urgent need to develop novel anti-Acinetobacter baumannii agents because the current anti-Acinetobacter baumannii agents are crucial in the fight against infections caused by drug-sensitive,while there are few options available for infections caused by panresistant or multidrug-resistant Acinetobacter baumannii.Indoles can act in various bacterial targets and have potential therapeutic effects on various Acinetobacter baumannii infections,representing useful scaffolds for exploring novel anti-Acinetobacter baumannii agents.The goal of this review is to give theoretical support for the future discovery of novel drug candidates by highlighting the current state of indole derivatives with promise against Acinetobacter baumannii that have been created between 2020 and the present.