苏州市吴江地区健康成年男性骨密度及身体成分情况分析

An Analysis of Bone Mineral Density and Body Composition of Healthy Adult Males in Wujiang Area of Suzhou City

目的调查苏州市吴江地区健康成年男性骨密度(bone mineral density,BMD)及身体成分分布情况,并探索两者之间相关性,为吴江地区男性骨骼肌肉疾病防治提供线索。方法2023年11月至2024年2月随机选取苏州市吴江区181名20~80岁健康成年男性志愿者为研究对象,获得其身高、体重等基础资料;采用双能X线吸收仪(DXA)检测腰椎(lumbar 2~4,L_(2~4))、左股骨颈(femoral neck,FN)、左总髋部(total hip,TH)的BMD,同时用该DXA测定体成分,包括全身脂肪质量(fat mass,FM)、全身瘦体质量(lean mass,LM)、去脂体重(fat-free mass,FFM)、腰臀比(android/gynoid ratio,A/G),计算体成分相关指数:体质量指数(body mass index,BMI)、脂肪质量指数(fat mass index,FMI)、瘦体质量指数(lean mass index,LMI)、去脂体重指数(fat-free mass index,FFMI)、脂肪百分比(percent of body fat,PBF);采用Pearson相关和多元线性回归模型分析所有因素与各部BMD的关系。结果(1)<50岁的男性骨量正常和骨量异常分别为27(58.70%)和19(41.30%)例,≥50岁的男性骨量正常和骨量异常分别为34(25.37%)和101(74.63%)例,分布差异有统计学意义(χ^(2)=17.243,P<0.01);(2)在<50岁组中,年龄与L_(2~4)及FN的BMD呈负相关(r=-0.331,P<0.05;r=-0.318,P<0.05),而与TH的BMD无相关性(P>0.05),A/G与所有部位BMD均无相关性(P>0.05),FMI和PBF与L_(2~4)的BMD无相关性(P>0.05);在≥50岁组中,年龄与FN及TH的BMD呈负相关(r=-0.250,P<0.01;r=-0.228,P<0.01),而与L_(2~4)的BMD无相关性(P>0.05),L_(2~4)和TH的BMD与身高无相关性(P>0.05);余所有指标与各部位BMD均呈正相关(P<0.05);(3)在<50岁组中,年龄进入L_(2~4)和FN BMD的回归模型中,LM进入所有部位BMD的回归模型中,在≥50岁组中,所有指标中只有LMI进入所有部位BMD的回归模型中,两个年龄组均未见FM或FMI进入回归模型中。结论LM和LMI分别是吴江区<50岁和≥50岁男性所有部位BMD的主要保护因素。

Objective To investigate the distribution of bone mineral density(BMD)and body composition in healthy adult males in Wujiang area of Suzhou city,and explore the correlation between them,so as to provide useful insights for the prevention and treatment of male skeletal muscle diseases in Wujiang area.Methods From November,2023 to February,2024,181 healthy adult male volunteers aged 20-80 years old from Wujiang District of Suzhou City were randomly selected as the study objects,and their basic information,such as height and weight were obtained.BMD of lumbar spine(L_(2-4)),left femoral neck(FN)and left common hip(TH)of these subjects were detected by dual-energy X-ray absorptiometry(DXA).Meanwhile,fat mass(FM),lean mass(LM),FAT-free mass(FFM),Android/Gynoid Ratio(A/G)were determined by DXA.The relevant indices,including body mass index(BMI),fat mass index(FMI),lean mass index(LMI),fat-free mass index(FFMI),and percent of body fat(PBF)were calculated.Pearson correlation analysis and multiple linear regression models were applied to analyze the relationship between all factors and BMD.Results Firstly,there were 27(58.70%)and 19(41.30%)cases of normal bone mass and abnormal bone mass in males<50 years old,and 34(25.37%)and 101(74.63%)cases of normal bone mass and abnormal bone mass in males≥50 years old,respectively,with a statistical difference(χ^(2)=17.243,P<0.01).Second,in the<50 years old group,age was negatively correlated with BMD of L_(2-4)and FN(r=-0.331,P<0.05;r=-0.318,P<0.05),while there was no correlation with TH BMD(P>0.05).A/G had no correlation with BMD of all studied parts(P>0.05),while FMI and PBF had no correlation with L_(2-4)BMD(P>0.05).In≥50 years old group,age was negatively correlated with BMD of FN and TH(r=-0.250,P<0.01;r=-0.228,P<0.01),but there was no correlation with BMD of L_(2-4)(P>0.05).BMD of L_(2-4)and TH was not correlated with height(P>0.05).All other indexes were positively correlated with BMD(P<0.05).Finally,in the<50 years old group,age entered the regression model of BMD for L_(2-4)and FN,and LM entered the regression model of BMD for all sites.In the≥50 years age group,only LMI of all indicators was included in the regression model of BMD at all sites.FM or FMI were not included in the regression model in either age group.Conclusion LM and LMI could be the main protective factors for BMD in men<50 years old and≥50 years old in Wujiang District area,respectively.