耳念珠菌基因组学研究综述

A review of the studies on genomics of Candida auris

耳念珠菌是一种具有多重耐药特性的真菌。目前基因组学研究显示,在基因组大小和演化方面,耳念珠菌与其他耐药酵母菌种有相似之处。耳念珠菌在不同地理群之间存在基因组大小差异和结构变异,可能与其表型和耐药性差异有关。耳念珠菌对多种抗真菌药物包括三唑类、两性霉素B和棘白菌素类药物均呈现耐药性。基因组学分析耳念珠菌耐药性可能与膜转运蛋白、麦角固醇途径突变等因素有关,并且在演化过程中,其耐药性可以进一步变化。本文对相关研究进行综述,以期了解耳念珠菌的耐药机制,为制定耳念珠菌的防控策略、治疗方案提供重要依据。

Candida auris(C.auris)is a fungus with multidrug resistance.Current genomic studies indicate that C.auris shares similarities in genome size and evolution with other resistant yeast species.There are differences in genome size and structural variations among different geographical clades of C.auris,which may be related to differences in phenotype and drug resistance.C.auris exhibits resistance to multiple antifungal agents,including triazole,amphotericin B,and echinocandins.Genomic studies have found that resistance of C.auris may be related to factors such as membrane transport protein and mutation in the ergosterol pathway,its resistance can change further during evolution.In this paper,the relevant studies are reviewed,with a view to understanding the mechanism of drug resistance of C.auris,and providing important basis for formulating prevention and control strategies as well as treatment programs of C.auris.