缬沙坦联合氨氯地平治疗老年高血压患者的临床效果

Clinical Effect Research of Valsartan Combined with Amlodipine in Treatment of Elderly Patients with Hypertension

目的探究缬沙坦联合氨氯地平治疗老年高血压患者的临床效果。方法选取2022年10月—2023年10月本院收治的老年高血压患者80例为研究对象,根据随机数字表法将其分为对照组和观察组,每组40例。对照组单独采用氨氯地平治疗,观察组联合应用缬沙坦与氨氯地平治疗,对比分析两组患者血压、24h尿蛋白及用药安全性。结果本次研究结果显示:观察组治疗有效率相较于对照组有明显的提升(P<0.05);干预前,两组24h尿蛋白定量和血压对比,无显著差异(P>0.05);干预后,两组舒张压与收缩压均降低,且观察组低于对照组(P<0.05);两组24h尿蛋白定量均升高,但观察组明低于对照组(P<0.05);观察组不良反应发生率相较于对照组更低(P<0.05)。结论应用缬沙坦联合氨氯地平对老年高血压患者进行干预治疗,可有效改善患者的血压及24h尿蛋白水平,安全有效,值得推广。

Objective:To investigate the clinical efficacy of valsartan combined with amlodipine in the treatment of elderly patients with hypertension.Method:80 elderly patients with hypertension admitted to our hospital from October 2022 to October 2023 were selected as the research subjects.They were randomly divided into a control group and an observation group using a random number table method,with 40 patients in each group.The control group was treated with amlodipine alone,while the observation group was treated with a comb ination of valsartan and amlodipine.The blood pressure,24-hour urinary protein,and medication safety of the two groups were compared and analyzed.The results of this study showed that the treatment efficacy of the observation group was significantly improved compared to the control group(P<0.05);Before intervention,there was no significant difference in 24-hour urine protein quantification and blood pressure between the two groups(P>0.05);After intervention,both diastolic and systolic blood pressure in the observation group showed a significant decrease compared to the control group(P<0.05).The 24-hour urinary protein quantification in the observation group was significantly higher than before intervention but lower than that in the control group after intervention(P<0.05);Adverse reaction statistics show that the incidence rate of the observation group is lower than that of the control group(P<0.05)..Conclusion:The application of valsartan combined with amlodipine in the intervention treatment of elderly hypertensive patients can effectively improve their blood pressure and 24-hour urinary protein levels,which is safe and effective,and worthy of promotion.