结直肠癌组织LncRNA SNHG15和miR-18a-5p表达与患者临床病理特征及预后的关系研究

Relationship between the Expression of LncRNA SNHG15 and miR-18a-5p in Colorectal Cancer Tissues and the Clinicopathological Features and Prognosis of Patients

目的:探讨结直肠癌组织长链非编码核糖核酸(LncRNA)小核仁RNA宿主基因15(SNHG15)和微小核糖核酸(mi R)-18a-5p表达与临床病理特征及预后的关系。方法:选取347例结直肠癌患者,检测癌组织和癌旁组织LncRNA SNHG15和mi R-18a-5p表达。随访3年,分析影响结直肠癌患者生存情况和影响预后的因素。结果:结直肠癌组织LncRNA SNHG15和mi R-18a-5p表达均高于癌旁组织(P<0.05)。分化程度低分化、TNM分期Ⅲ期、淋巴结转移结直肠癌患者的LncRNA SNHG15和mi R-18a-5p表达高于中高分化、TNM分期Ⅰ~Ⅱ期、无淋巴结转移结直肠癌患者(P<0.05)。LncRNA SNHG15高表达、mi R-18a-5p高表达结直肠癌患者3年总生存(OS)率低于LncRNA SNHG15低表达、mi R-18a-5p低表达结直肠癌患者(P<0.05)。分化程度低分化、TNM分期Ⅲ期、淋巴结转移、高表达LncRNA SNHG15、高表达mi R-18a-5p是结直肠癌患者死亡的危险因素(P<0.05)。结论:结直肠癌组织中LncRNA-SNHG15、mi R-18a-5p表达升高,与结直肠癌患者的分化程度低分化、TNM分期Ⅲ期、淋巴结转移等恶性病理特征及不良预后的发生有关。

Objective:To investigate the relationship between the expression of long non-coding RNA(LncRNA)small nucleolar RNA host gene 15(SNHG15)and microRNA(miR)-18a-5p in colorectal cancer tissues and clinicopathological features and prognosis.Methods:347 patients with colorectal cancer were selected,the cancer tissues and adjacent tissues for LncRNA SNHG15 and miR-18a-5p expression were detection.Followed up for 3 years.The survival status and the factors affecting the prognosis of patients with colorectal cancer were analyzed.Results:The expression of LncRNA SNHG15 and miR-18a-5p in colorectal cancer tissues were higher than those in adjacent tissues(P<0.05).The expression of LncRNA SNHG15 and miR-18a-5p in colorectal cancer patients with low degree of differentiation,TNM stage Ⅲ and lymph node metastasis were higher than those in patients with well-differentiated,TNM stage Ⅰ-Ⅱ and no lymph node metastasis(P<0.05).The 3-year overall survival(OS)rate in colorectal cancer patients with high expression of LncRNA SNHG15 and high expression of miR-18a-5p was lower than that in colorectal cancer patients with low expression of LncRNA SNHG15 and low expression of miR-18a-5p(P<0.05).Low degree of differentiation,TNM stage Ⅲ,lymph node metastasis,high expression of LncRNA SNHG15 and high expression of miR-18a-5p were risk factors for death in patients with colorectal cancer(P<0.05).Conclusion:The expression of LncRNA-SNHG15 and miR-18a-5p in colorectal cancer tissues are increased,which are related to the occurrence of malignant pathological features and poor prognosis of colorectal cancer patients,such as low degree of differentiation,TNM stage Ⅲ,lymph node metastasis and so on.