清热祛湿汤联合湿润烧伤膏对湿热下注型高位复杂性肛瘘术后患者创面愈合、肛门功能和生长因子的影响

Effect of Qingre Qushi Decoction Combined with Moist Exposed Burn Ointment on Wound Healing,Anal Function and Growth Factors in Patients with High Complex Anal Fistula of Damp-Heat Injection Type after Operation

目的:探讨湿润烧伤膏联合清热祛湿汤在湿热下注型高位复杂性肛瘘术后患者创面愈合、肛门功能和生长因子的影响。方法:将我院90例湿热下注型高位复杂性肛瘘术后患者随机分为对照组(接受湿润烧伤膏治疗,45例)和治疗组(对照组基础上接受清热祛湿汤,45例)。对比两组疗效、创面愈合指标、肛门功能指标、生长因子指标变化情况。结果:对照组总有效率低于治疗组(P<0.05)。相较对照组而言,治疗组的创面愈合率更高,创面渗液量更少,创面最大纵径、创面最大横径更小(P<0.05)。相较对照组治疗1个月后而言,治疗组的肛管最大收缩压(AMCP)、肛管最长收缩时间(ALCT)、肛管静息压(ARP)、成纤维细胞生长因子(b FGF)、表皮生长因子(EGF)、转化生长因子β(TGF-β)更高(P<0.05)。结论:清热祛湿汤联合湿润烧伤膏用于湿热下注型高位复杂性肛瘘术后患者,可有效促进创面愈合,改善肛门功能,提高临床疗效。

Objective:To investigate the effects of moist exposed burn ointment combined with qingre qushi decoction on wound healing,anal function and growth factors in patients with high complex anal fistula of damp-heat injection type after operation.Methods:90 patients with high complex anal fistula of damp-heat betting type who were randomly divided into control group(treated with moist exposed burn ointment,45 cases)and treatment group(on the basis of control group receive qingre qushi decoction,45 cases).The curative effect,wound healing index,anal function index and growth factor index in two groups were compared.Results:The total effective rate of the control group was lower than that of the treatment group(P<0.05).Compared with control group,the wound healing rate in treatment group was higher,the wound exudation was less,the maximum longitudinal diameter of the wound and the maximum transverse diameter of the wound were smaller(P<0.05).Compared with control group 1 month after treatment,the anal maximum systolic pressure(AMCP),anal maximum contraction time(ALCT)and anal resting pressure(ARP),the fibroblast growth factor(bFGF),epidermal growth factor(EGF),and transforming growth factorβ(TGF-β)in treatment group were higher(P<0.05).Conclusion:Qingre qushi decoction combined with moist exposed burn ointment can effectively promote wound healing,improve anal function and improve clinical efficacy in patients with high complex anal fistula after damp-heat injection.