机械振动排痰联合氧驱动雾化吸入对喘息性支气管肺炎患儿肺功能、炎症反应及血氧饱和度水平的影响

Effects of Mechanical Vibration Expectoration Combined with Oxygen-Driven Aerosol Inhalation on Lung Function,Inflammatory Response and Blood Oxygen Saturation Level in Children with Asthmatic Bronchial Pneumonia

目的:探讨机械振动排痰联合氧驱动雾化吸入对喘息性支气管肺炎患儿肺功能、炎症反应及血氧饱和度(SaO_(2))水平的影响。方法:92例喘息性支气管肺炎患儿采用随机数字表法分为对照组(氧驱动雾化吸入治疗,n=46)和研究组(机械振动排痰联合氧驱动雾化吸入治疗,n=46)。对比两组疗效、肺功能[达峰时间比(TPTEF/TE)、达峰容积比(VPEF/VE)、潮气量(VT)]、炎症反应[白细胞计数、中性粒细胞计数、淋巴细胞和C反应蛋白(CRP)]和SaO_(2)变化情况,同时观察两组不良反应发生情况。结果:与对照组比较,研究组的白细胞计数、中性粒细胞计数、淋巴细胞、CRP更低,临床总有效率、TPTEF/TE、VPEF/VE、VT、SaO_(2)更高(P<0.05)。两组不良反应发生率对比未见差异(P>0.05)。结论:氧驱动雾化吸入和机械振动排痰联合治疗喘息性支气管肺炎,可有效减轻炎症反应,改善SaO_(2)水平,改善患儿肺功能,提高临床治疗效果。

Objective:To investigate the effects of mechanical vibration expectoration combined with oxygen-driven aerosol inhala-tion on lung function,inflammatory response and blood oxygen saturation(SaO_(2))level in children with asthmatic bronchial pneumonia.Methods:92 children with asthmatic bronchial pneumonia were divided into control group(oxygen-driven aerosol inhalation therapy,n=46)and study group(mechanical vibration expectoration combined with oxygen-driven aerosol inhalation therapy,n=46)by random number table method.The efficacy,lung function[peak time ratio(TPTEF/TE),peak volume ratio(VPEF/VE),tidal volume(VT)],inflam-matory response[white blood cell count,neutrophil count,lymphocyte and C-reactive protein(CRP)]and SaO_(2) were compared between two groups,and the incidence of adverse reactions was observed between two groups.Results:Compared with control group,The white blood cell count,neutrophil count,lymphocyte and CRP in study group were lower,and the total clinical effective rate,TPTEF/TE,VPEF/VE,VT and SaO_(2) were higher(P<0.05).There was no difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion:The combination of oxygen-driven aerosol inhalation and mechanical vibration expectoration in the treat-ment of asthmatic bronchial pneumonia,which can effectively reduce the inflammatory response,improve the level of SaO_(2),improve the lung function of children,and improve the clinical treatment effect.