血清sCD14、HMGB1水平与口腔正畸患者发生交叉感染的关系研究

Study of the relationship between serum sCD14,HMGB1 levels and cross-infection in orthodontic patients

目的探究血清可溶性CD14(sCD14)、高迁移率族蛋白B1(HMGB1)水平与口腔正畸患者发生交叉感染的关系及二者对患者发生交叉感染的预测价值。方法以新疆医科大学第一附属医院2018年1月—2022年1月收治的183例口腔正畸患者作为研究对象,其中口腔正畸治疗过程发生交叉感染的患者93例作为感染组,未出现交叉感染的患者90例作为对照组。采用ELISA法检测研究对象血清sCD14、HMGB1水平;多因素logistic回归分析研究口腔正畸患者发生交叉感染的影响因素;ROC曲线分析sCD14、HMGB1与口腔正畸患者发生交叉感染的关系。结果与对照组相比,感染组血清sCD14、HMGB1表达水平显著升高(P<0.05);高水平血清sCD14、HMGB1是口腔正畸患者发生交叉感染的独立危险因素;血清sCD14、HMGB1预测口腔正畸患者发生交叉感染的AUC分别为0.769、0.783,两者联合预测口腔正畸患者发生交叉感染的AUC为0.886,均高于sCD14、HMGB1单独检测(P<0.001)。结论发生交叉感染的口腔正畸患者血清sCD14、HMGB1水平升高,两者联合检测对口腔正畸患者是否发生交叉感染具有一定的预测价值。

Objective To investigate the relationship between serum soluble cluster of differentiation antigen 14(sCD14)and high mobility group B1(HMGB1)levels and the occurrence of cross-infection in orthodontic patients,as well as their predictive value for cross-infection.Methods A total of 183 orthodontic patients admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2018 to January 2022 were taken as the study object.Among them,93 cases with cross-infection during orthodontic treatment were taken as the infection group,while 90 cases without cross-infection were taken as the control group.The levels of serum sCD14 and HMGB1 were detected by enzyme-linked immunosorbent assay(ELISA).Multivariate logistic regression was used to analyze the influencing factors of cross-infection,and the relationship between sCD14,HMGB1,and cross infection in orthodontic patients was analyzed by ROC curves.Results Compared with the control group,the levels of serum sCD14 and HMGB1 in the infection group were obviously higher(P<0.05).Elevated levels of serum sCD14 and HMGB1 were independent risk factors for cross-infection in orthodontic patients(P<0.05).The area under the curve(AUC)for predicting cross-infection was 0.769 for sCD14 and 0.783 for HMGB1.The combined AUC of both markers was 0.886,significantly higher than that for either marker alone(P<0.001).Conclusion Increased serum levels of sCD14 and HMGB1 are increased with cross-infection in orthodontic patients,and their combined detection offers strong predictive value for the occurrence of cross-infection.