自拟荜芨汤联合西药对慢性萎缩性胃炎患者糖类抗原72-4、胃蛋白酶原及免疫球蛋白的影响

The effects of self-made Biji Tang combined with Western medicine on carbohydrate antigen 72-4,pepsinogen,and immunoglobulin in patients with chronic atrophic gastritis

目的:探讨慢性萎缩性胃炎患者联合服用自拟荜芨汤和西药后对血清中的糖类抗原72-4、胃蛋白酶原以及免疫球蛋白含量的影响。方法:于服药前后分别对患者进行空腹采血(黄色分离胶),进行离心处理后检测其血清糖类抗原72-4(CA72-4)、胃蛋白酶原(PGⅠ、PGⅡ)及免疫球蛋白(IgG、IgA、IgM)的含量,并分析其临床疗效和中医证候积分。结果:治疗后观察组相比于对照组CA72-4水平明显减低(P<0.05),PGⅠ、PGⅠ/PGⅡ水平明显升高(P<0.05),PGⅡ水平明显减低(P<0.05),免疫球蛋白水平明显升高(P<0.05),治疗后观察组的有效率96.30%明显高于对照组72.23%,差异有统计学意义(χ^(2)=20.17,P<0.05)。结论:自拟荜芨汤联合西药对慢性萎缩性胃炎疗效显著。

Objective:Exploring the effects of self formulated Biji Tang and Western medicine on the levels of carbohydrate antigen 72-4,pepsinogen,and immunoglobulin in the serum of patients with chronic atrophic gastritis.Methods:Fasting blood samples(yellow separation gel)were collected from each patient before and after medication.After centrifugation,the serum levels of carbohydrate antigen 72-4(CA72-4),pepsinogen(PG I,PG II),and immunoglobulins(IgG,IgA,IgM)were measured,and their clinical efficacy and TCM syndrome scores were analyzed.Results:After treatment,the observation group showed a significant decrease in CA724 levels compared to the control group(P<0.05),with a significant increase in PG I and PG I/PG II levels(P<0.05),a significant decrease in PG II levels(P<0.05),The effective rate of the observation group 96.30%after treatment was significantly higher than that of the control group 72.23%,with statistical significance(χ^(2)=20.17,P<0.05).Conclusion:The combination of self-designed Biji Tang and Western medicine has a significant therapeutic effect on chronic atrophic gastritis.