基于数据挖掘技术探讨中药治疗慢性前列腺炎伴性功能障碍用药规律

Medication Rule of Chinese Medicinals in Treating Chronic Prostatitis with Sexual Dysfunction Based on Data Mining

目的:基于数据挖掘技术探讨中药治疗慢性前列腺炎(CP)伴性功能障碍的用药规律。方法:检索中国知网(CNKI)、中文科技期刊数据库(VIP)、万方数据知识服务平台(Wanfang)、中国生物医学文献数据库(CBM)中中药治疗CP伴性功能障碍的临床文献,时限为从建库至2023年11月5日,运用Excel软件统计中药使用频次、性味、归经及功效,SPSS statistic26进行关联规则分析,SPSS Modeler18行聚类分析。结果:纳入52篇文献,包括59个中药处方,涉及中药158味。药物使用总频次为626次,使用频次≥10次的药物有车前子、柴胡、黄柏、淫羊藿、丹参、茯苓、甘草、山萸肉、菟丝子、赤芍等。药性排前3的依次是寒、温、平性。药味排前3的依次是甘、苦、辛味。归经排前3的依次是肝、肾、脾经。功效使用频次排前6的依次是补虚药、活血化瘀药、清热药、利水渗湿药、理气药及收涩药。关联规则分析得到置信度及支持度最高的为熟地黄、山药、山萸肉组合。通过聚类分析挖掘出3种组方,分别适合于肾阴阳两虚证、肝郁脾虚夹湿热证、湿热夹瘀证。结论:临床治疗CP伴性功能障碍常使用车前子、柴胡、黄柏、淫羊藿、丹参等中药,以补虚活血、清热利湿、理气为主,符合该病肾虚肝郁、湿热瘀滞的主要病机。

Objective:To explore the medication rule of using Chinese medicinals to treat chronic prostatitis(CP)with sexual dysfunction based on data mining.Methods:The literatures of clinical on using Chinese medicinals to treat CP with sexual dysfunction were retrieved from CNKI,VIP,Wanfang and CBM.The time period was from the establishment day of the database to November 5,2023.Excel software was used to make statistics on the usage frequency,natures and flavors,channel entry and effect of the Chinese medicinals;SPSS statistic26 was used for association rule analysis,and SPSS Modeler 18 was used for cluster analysis.Results:A total of 52 literatures were involved,which included 59 Chinese medicinal prescriptions,and 158 kinds of Chinese medicinals.The total frequency of medicinal use was 626 times,and the usage frequency higher than 10 times were included Plantaginis Semen,Bupleuri Radix,Phellodendri Chinensis Cortex,Epimedii Folium,Salviae Miltiorrhizae Radix et Rhizoma,Poria,Glycyrrhizae Radix et Rhizoma,Corni Fructus,Cuscutae Semen and Paeoniae Radix Rubra.The top three medicinal natures were cold,warm and neutral.The top three medicinal flavors were sweet,bitter and acrid.The top three channel entries were the liver,kidney and spleen channels.The top six effect of medicinal types in terms of usage frequency were medicinals for tonifying deficiency,invigorating blood and dissolving stasis,clearing heat,promoting urination and percolating dampness,regulating qi,and astringing.Association rule analysis showed that the combination of Rehmanniae Radix Praeparata,Dioscoreae Rhizoma and Corni Fructus had the highest degree of confidence and support.Three kinds of combination prescriptions were found by cluster analysis,which were suitable for syndrome of kidney yin-yang deficiency,syndrome of liver constraint and spleen deficiency with damp-heat,and syndrome of damp-heat with stasis.Conclusion:In the clinical treatment of CP with sexual dysfunction,Chinese medicinals such as Plantaginis Semen,Bupleuri Radix,Phellodendri Chinensis Cortex,Epimedii Folium,and Salviae Miltiorrhizae Radix et Rhizoma are commonly used.These medicines primarily serve to tonify dificiency and invigorate blood,clear heat and remove dampness,and regulate qi,which is in line with the main pathogenesis of kidney deficiency and liver stagnation and damp-heat and blood stasis.