柴胡桂枝汤对肝气郁结型广泛性焦虑症患者疼痛的影响

Effect of Chaihu Guizhi Decoction on Pain of Patients with Generalized Anxiety Disorder of Binding Constraint of Liver Qi Type

目的:观察柴胡桂枝汤治疗肝气郁结型广泛性焦虑症的临床疗效及对疼痛的影响。方法:按随机数字表法将102例肝气郁结型广泛性焦虑症患者分为治疗组和对照组各51例。治疗组采用柴胡桂枝汤治疗,对照组采用常规西药治疗。比较2组治疗前后视觉模拟评分法(VAS)评分、汉密尔顿焦虑量表(HAMA)评分、中医证候评分及血清神经递质[去甲肾上腺素(NE)、多巴胺(DA)]水平,并评估2组临床疗效及不良反应发生情况。结果:治疗组总有效率88.24%,高于对照组68.63%(P<0.05)。治疗后,2组VAS评分、HAMA评分、中医证候评分及血清NE、DA水平均低于治疗前(P<0.05),且治疗组上述3项评分及血清神经递质水平低于对照组(P<0.05)。治疗组不良反应发生率1.96%,低于对照组13.73%(P<0.05)。结论:柴胡桂枝汤治疗肝气郁结型广泛性焦虑症疗效确切,能够有效缓解患者疼痛及焦虑程度,调节神经递质水平,安全性较高。

Objective:To observe the clinical effect of Chaihu Guizhi Decoction on generalized anxiety disorder of binding constraint of liver qi type and its effect on pain.Methods:A total of 102 patients with generalized anxiety disorder of binding constraint of liver qi type were divided into the treatment group and the control group according to the random number table method,with 51 cases in each group.The treatment group was treated with Chaihu Guizhi Decoction,and the control group was treated with routine western medicine.The scores of Visual Analogue Scale(VAS)and Hamilton Anxiety Scale(HAMA),traditional Chinese medicine(TCM)syndrome scores and levels of serum neurotransmitters[norepinephrine(NE)and dopamine(DA)]were compared before and after treatment between the two groups;the clinical effects and incidence of adverse reactions in the two groups were evaluated.Results:The total effective rate was 88.24%in the treatment group,higher than that of 68.63%in the control group(P<0.05).After treatment,the scores of VAS and HAMA,TCM syndrome scores and levels of serum NE and DA in the two groups were lower than those before treatment(P<0.05),and the in the treatment group were lower than those in the control group(P<0.05).The incidence of adverse reactions was 1.96%in the treatment group,lower than that of 13.73%in the control group(P<0.05).Conclusion:Chaihu Guizhi Decoction has a definite curative effect on generalized anxiety disorder of binding constraint of liver qi type,which can effectively relieve the pain and anxiety of patients and regulate the levels of neurotransmitters with great safety.