麦粒灸联合多巴丝肼治疗帕金森病对认知功能和血清Hcy、NSE水平的影响

Effect of Wheat-Grain Size Cone Moxibustion Combined with Levodopa and Benserazide Hydrochloride on Cognitive Function and Levels of Serum Hcy and NSE in Treatment of Parkinson's Disease

目的:观察麦粒灸联合多巴丝肼治疗帕金森病(PD)对患者认知功能和血清Hcy、NSE水平的影响。方法:选取帕金森病患者106例,按照随机抽签法将其分为联合组和对照组各53例。对照组采用多巴丝肼进行治疗,联合组在对照组的基础上加用麦粒灸治疗。比较2组治疗前后中医证候评分、帕金森病统一量表(UPDRS)评分、简易智力状态检查量表(MMSE)评分、血清同型半胱氨酸(Hcy)、神经元特异性烯醇化酶(NSE)水平变化,比较2组不良反应发生情况。结果:治疗后,2组中医证候评分均较治疗前下降(P<0.05),且联合组中医证候评分低于对照组(P<0.05)。治疗后,2组UPDRS量表中精神状态、日常生活活动能力、运动检查以及运动并发症评分均较治疗前下降(P<0.05),且联合组各项评分均低于对照组(P<0.05)。治疗后,2组MMSE评分均较治疗前升高(P<0.05),且联合组MMSE评分高于对照组(P<0.05)。治疗后,2组血清Hcy、NSE水平均较治疗前下降(P<0.05),且联合组Hcy、NSE水平低于对照组(P<0.05)。联合组不良反应发生率为15.09%,对照组为5.66%,2组比较,差异无统计学意义(P>0.05)。结论:麦粒灸联合多巴丝肼治疗PD可改善临床症状,降低血清Hcy、NSE水平,提高患者认知功能。

Objective:To observe the effect of wheat-grain size cone moxibustion combined with Levodopa and Benserazide Hydrochloride on cognitive function and levels of serum homocysteine(Hcy)and neuron-specific enolase(NSE)in the treatment of Parkinson's disease(PD).Methods:A total of 106 cases of PD patients were selected and randomly divided into the combination group and the control group,with 53 cases in each group.The control group was treated with Levodopa and Benserazide Hydrochloride,and the combination group was additionally treated with wheat-grain size cone moxibustion based on the treatment of the control group.Changes in traditional Chinese medicine(TCM)syndrome scores,the scores of the Unified Parkinson's Disease Rating Scale(UPDRS)and the Mini-Mental Status Exam(MMSE),and the levels of serum Hcy and NSE were compared between the two groups before and after treatment.The incidence of adverse reactions was compared between the two groups.Results:After treatment,TCM syndrome scores in the two groups were declined when compared with those before treatment(P<0.05),and TCM syndrome scores in the combination group were lower than those in the control group(P<0.05).After treatment,the scores of mentation,activities of daily living,motor examination,and motor complications in UPDRS in the two groups were reduced when compared with those before treatment(P<0.05),and each score in the combination group was lower than that in the control group(P<0.05).After treatment,the scores of MMSE in the two groups were elevated when compared with those before treatment(P<0.05),and the scores of MMSE in the combination group were lower than those in the control group(P<0.05).After treatment,the levels of serum Hcy and NSE in the two groups were declined when compared with those before treatment(P<0.05),and the levels of serum Hcy and NSE in the combination group were lower than those in the control group(P<0.05).The incidence of adverse reactions was 15.09%in the combination group and 5.66%in the control group,there being no significance in the difference(P>0.05).Conclusion:In the treatment of PD,wheat-grain size cone moxibustion combined with Levodopa and Benserazide Hydrochloride can improve clinical symptoms and cognitive function of patients,and reduce the levels of serum Hcy and NSE.