基于“肺-膜腠三焦-肾”系统探讨“伏邪”介导慢性肾小球肾炎蛋白尿的机制

Exploration on the mechanism of proteinuria in chronic glomerulonephritis mediated by the‘latent pathogens’based on the‘lung-membranous triple energizer-kidney’system

文章分“冬伤于寒,春必病温”“冬不藏精,春必病温”“伤寒之中,最多杂病”三层阐述“伏邪”内核。基于“膜腠三焦”理论,融合中医理论与现代医学研究提出“肺-膜腠三焦-肾”系统构建人体生命通道,并尝试从微观比类方式证明肾小球滤过屏障可能是“肺-膜腠三焦-肾”系统在肾系的重要通道。认为“伏邪”与“肺-膜腠三焦-肾”系统在病机学层面高度关联,分5个阶段阐述“肺-膜腠三焦-肾”系统失衡、内外诸邪暗伏肾系引发慢性肾小球肾炎蛋白尿的病机,为中医从“通道-伏邪”论治慢性肾炎蛋白尿提供理论依据。

The article is divided into three layers to explain the core of‘latent pathogens’:‘If one is injured by the cold in winter,they are sure to fall ill with fever in the spring’‘If one does not conserve one’s essence during the winter,they are sure to fall ill with fever in the spring’,and‘among typhoid fever,the most common is miscellaneous diseases’.Based on the theory of‘membranous triple energizer’,this paper proposes the‘lung-membranous triple energizer-kidney’system to build the vital channel of human body,and tries to prove from microscopic analogy that the glomerular filtration barrier may be an important channel of the‘lung-membranous triple energizer-kidney’system in the kidney system.It is believed that the‘latent pathogens’and the‘lung-membranous triple energizer-kidney’system are highly related at the pathogenic level.The pathological mechanism of proteinuria in chronic glomerulonephritis caused by imbalance in the‘lung-membranous triple energizer-kidney’system and the internal and external evils in the kidney system are explained in five stages,providing a theoretical basis for the treatment of proteinuria in chronic glomerulonephritis in Chinese medicine from the‘channel-latent pathogens’theory.