乌司他丁联合血液灌流对急诊有机磷中毒患者临床指标及肝肾功能的影响

Impact of Ulinastatin Combined with Hemoperfusion on Clinical Indicators,Liver and Kidney Function of Patients with Emergency Organophosphorus Poisoning

目的探讨乌司他丁联合血液灌流对急诊有机磷中毒患者临床指标及肝肾功能的影响。方法选取我院收治的有机磷中毒患者60例,根据治疗方法不同分为参照组(30例,常规治疗+血液灌流)和观察组(30例,常规治疗+乌司他丁+血液灌流)。比较两组患者的临床指标(意识恢复时间、胆碱酯酶恢复时间)及肝肾功能。结果观察组意识恢复时间、胆碱酯酶恢复时间均短于参照组(P<0.05)。治疗7 d后,观察组的ALT、AST、Scr、BUN水平均低于参照组(P<0.05)。结论乌司他丁联合血液灌流治疗可明显缩短急诊有机磷中毒患者的意识恢复时间和胆碱酯酶恢复时间,改善其肝肾功能,值得临床推广应用。

Objective To explore the impact of ulinastatin combined with hemoperfusion on clinical indicators,liver and kidney function of patients with emergency organophosphorus poisoning.Methods 60 cases of patients with organophosphorus poisoning admitted to our hospital were selected and divided into reference group(30 cases,routine treatment+hemoperfusion)and observation group(30 cases,routine treatment+ulinastatin+hemoperfusion)according to different treatment methods.The clinical indicators(consciousness recovery time,cholinesterase recovery time),liver and kidney function were compared between the two groups.Results The consciousness recovery time and cholinesterase recovery time of the observation group were shorter than those of the reference group(P<0.05).After 7 days of treatment,the ALT,AST,Scr and BUN levels of the observation group were lower than those of the reference group(P<0.05).Conclusions Ulinastatin combined with hemoperfusion can significantly shorten the recovery time of consciousness and cholinesterase recovery time in patients with emergency organophosphorus poisoning,and improve the liver and kidney function of patients,which is worthy of clinical promotion and application.