氨甲苯酸联合艾司奥美拉唑对非静脉曲张性上消化道出血的治疗效果

Treatment Effect of Aminomethylbenzoic Acid Combined with Esomeprazole on Non-Variceal Upper Gastrointestinal Bleeding

目的探讨氨甲苯酸联合艾司奥美拉唑治疗非静脉曲张性上消化道出血(NVUGIB)的临床效果。方法选取2021年1月至2023年7月我院收治的90例NVUGIB患者,随机分为单一组(45例)和联合组(45例)。单一组采用艾司奥美拉唑治疗,联合组采用氨甲苯酸联合艾司奥美拉唑治疗。比较两组的临床疗效、凝血功能指标及不良反应。结果联合组治疗总有效率为91.11%,明显高于单一组的73.33%(P<0.05)。治疗5 d后,两组的活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)短于治疗前,纤维蛋白原(FIB)水平高于治疗前(P<0.05);联合组PT、APTT短于单一组,FIB水平高于单一组(P<0.05)。联合组不良反应发生率为11.11%,与单一组的6.67%比较差异无统计学意义(P>0.05)。结论氨甲苯酸联合艾司奥美拉唑治疗可明显改善NVUGIB患者的凝血功能,疗效确切且安全可靠,值得临床推广应用。

Objective To explore the clinical effect of aminomethylbenzoic acid combined with esomeprazole in the treatment of non-variceal upper gastrointestinal bleeding(NVUGIB).Methods 90 NVUGIB patients admitted to our hospital from January 2021 to July 2023 were selected and randomly divided into single group(45 cases)and combined group(45 cases).The single group was treated with esomeprazole,and the combined group was treated with aminomethylbenzoic acid combined with esomeprazole.The clinical efficacy,coagulation function indicators and adverse reactions of the two groups were compared.Results The total effective rate of treatment in the combined group was 91.11%,significantly higher than 73.33%in the single group(P<0.05).After 5 days of treatment,the APTT and PT were shorter than those before treatment,and the FIB levels were higher than those before treatment(P<0.05);The APTT and PT of the combined group were shorter than those of the single group,and the FIB level was higher than that of the single group(P<0.05).The incidence of adverse reactions in the combined group was 11.11%,which had no statistical difference with 6.67%in the single group(P>0.05).Conclusions Aminomethylbenzoic acid combined with esomeprazole can significantly improve the coagulation function of NVUGIB patients,has definite treatment effect and is safe and reliable,which is worthy of clinical promotion and application.