地塞米松结合左氧氟沙星治疗化脓性中耳炎的效果及对患者听力水平、炎性指标的影响

Effect of Dexamethasone Combined with Levofloxacin in the Treatment of Suppurative Otitis Media and the Impact on Hearing Level and Inflammatory Indicators of Patients

目的探讨地塞米松结合左氧氟沙星治疗化脓性中耳炎患者的效果。方法选择2021年5月至2022年6月我院收治的68例化脓性中耳炎患者,随机分为两组各34例。对照组采用左氧氟沙星治疗,观察组采用地塞米松结合左氧氟沙星治疗,两组均治疗7 d。比较两组的临床疗效、听力水平、炎性指标及不良反应。结果观察组治疗总有效率高于对照组(P<0.05)。治疗后,观察组气导听力损失、骨导听力损失水平及血清CRP、IL-6、TNF-α水平低于对照组(P<0.05)。两组的不良反应发生率比较差异无统计学意义(P>0.05)。结论地塞米松结合左氧氟沙星治疗化脓性中耳炎的效果确切,可恢复患者听力,抑制机体炎性反应,且安全性高。

Objective To explore the effect of dexamethasone combined with levofloxacin in the treatment of suppurative otitis media.Methods 68 patients with suppurative otitis media admitted to our hospital from May 2021 to June 2022 were selected and randomly divided into two groups,with 34 cases in each group.The control group was treated with levofloxacin,and the observation group was treated with dexamethasone combined with levofloxacin.Both groups were treated for 7 days.The clinical efficacy,hearing level,inflammatory indicators and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of air conduction hearing loss,bone conduction hearing loss,and the serum CRP,IL-6 and TNF-αin the observation group were lower than those in the control group(P<0.05).No statistical difference was found in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Dexamethasone combined with levofloxacin has definite effect in the treatment of suppurative otitis media,which can restore the patients'hearing,and inhibit the inflammatory response,with high safety.