甲泼尼龙琥珀酸钠联合阿奇霉素治疗对肺炎支原体肺炎患儿肺部炎症及肺功能的影响

Impact of Methylprednisolone Sodium Succinate Combined with Azithromycin on Pulmonary Inflammation and Pulmonary Function in Children with Mycoplasma Pneumoniae Pneumonia

目的探讨甲泼尼龙琥珀酸钠联合阿奇霉素治疗对肺炎支原体肺炎(MPP)患儿肺部炎症及肺功能的影响。方法选取我院收治的122例MPP患儿,随机分为两组各61例。对照组采用阿奇霉素治疗,研究组采用甲泼尼龙琥珀酸钠联合阿奇霉素治疗,均治疗7 d。比较两组患儿的临床症状改善情况、肺部炎症相关指标、肺功能指标。结果研究组咳嗽缓解时间、体温恢复正常时间、肺部啰音消失时间短于对照组(P<0.05)。治疗7 d后,研究组的血清IL-6、CRP、PCT水平低于对照组,FEV1、MMV及FEV1/FVC高于对照组(P<0.05)。结论甲泼尼龙琥珀酸钠联合阿奇霉素治疗可促进MPP患儿临床症状尽快缓解,明显减轻患儿的肺部炎症,改善其肺功能。

Objective To explore the impact of methylprednisolone sodium succinate combined with azithromycin on pulmonary inflammation and pulmonary function in children with mycoplasma pneumoniae pneumonia(MPP).Methods 122 MPP children admitted to our hospital were selected and randomly divided into the two groups,with 61 cases in each group.The control group was treated with azithromycin,and the study group was treated with methylprednisolone sodium succinate combined with azithromycin.Both groups were treated for 7 days.The improvement of clinical symptoms,pulmonary inflammation related indicators and pulmonary function indicators were compared between the two groups.Results The cough relief time,body temperature recovery time and pulmonary rale disappearance time of the study group were shorter than those of the control group(P<0.05).After 7 days of treatment,the serum IL-6,CRP and PCT levels of the study group were lower than those of the control group,and the FEV1,MMV and FEV1/FVC were higher than those of the control group(P<0.05).Conclusions Methylprednisolone sodium succinate combined with azithromycin can promote the rapid relief of clinical symptoms in MPP children,and significantly reduce the pulmonary inflammation and improve the pulmonary function.