科学认识中药安全性 加强风险管理

Scientifically understand the safety of traditional Chinese medicine and strengthen risk management

中药安全性问题已受到社会广泛关注,是中药进一步发展和国际化的主要障碍。中药安全性研究的难点主要来自中药的复杂性和药物-机体相互作用的不可预测性。导致中药安全性的原因多样,包括中药的内在及外在毒性、临床实践中基源混用和不合理使用、患者安全用药意识不足,以及目前对中药质量安全的监管体系不够完善等。应加强中药安全性风险管理,包括应用科学技术探究中药安全性本质、利用人工智能开展大数据分析并实现风险早期预警、传递安全使用中药科学理念、建立全生命周期中药药物警戒体系等。这将有益于我国中药安全性研究,保障患者用药安全,促进中医药产业健康持续发展和国际化。

The safety of traditional Chinese Medicine(TCM)has garnered widespread attention and has become a major obstacle to its further development and internationalization.The complexity of TCM and the unpredictability of its interactions with the human body pose significant challenges to safety research.The causes of TCM safety issues are multifaceted,including intrinsic and extrinsic toxicity,confusion of herbal sources and misuse in clinical practice,inadequate patient awareness of safe medication use,and insufficient regulatory oversight of TCM quality and safety.To strengthen the risk managements,it is essential to employ scientific technologies to investigate the fundamental nature of TCM safety,leverage artificial intelligence for big data analysis and early risk warning,promote the scientific concept of safe TCM use,and establish a comprehensive lifecycle pharmacovigilance system for TCM.These will facilitate TCM safety research in China,ensure patient medication safety,and promote the healthy and sustainable development of the TCM industry and its internationalization.