肌肉减少症与全因死亡率的关联:基于2011―2020年CHARLS数据的研究

Association between sarcopenia and all-cause mortality:a study based on 2011-2020 CHARLS data

目的探讨肌肉减少症与≥45岁成年人全因死亡率之间的关系。方法基于中国健康与养老追踪调查(China health and retirement longitudinal study,CHARLS)2011―2020年的数据,根据亚洲肌肉减少症工作组(Asian working group for sarcopenia,AWGS)2019年的标准对肌肉减少症进行诊断。利用logistic回归分析模型计算个体倾向得分(propensity score,PS),然后使用逆概率加权(inverse probability of treatment weighting,IPTW)法进行Cox比例风险回归模型分析。结果研究共纳入12241名参与者:7279名正常参与者,3036名参与者可能患有肌肉减少症,1926名参与者患有肌肉减少症。IPTW法加权后,与无肌肉减少症的参与者相比,可能肌肉减少症的参与者死亡风险增加了46%(HR=1.46,95%CI:1.19~1.77),肌肉减少症的参与者死亡风险增加了99%(HR=1.99,95%CI:1.43~2.76)。结论肌肉减少症与≥45岁成年人全因死亡率之间存在关联,肌肉减少症会增加≥45岁成年人的死亡风险。

Objective To explore the association between sarcopenia and all-cause mortality in adults aged 45 and older.Methods Data from the China health and retirement longitudinal study(CHARLS)from 2011-2020 were utilized.Sarcopenia was diagnosed according to the 2019 standards set by the Asian Working Group for Sarcopenia(AWGS).The logistic regression model was used to calculate the individual propensity score(PS),and then the inverse probability of treatment weighting(IPTW)method was employed to perform Cox proportional hazard regression model analysis.Results The study included 12241 participants:7279 participants without sarcopenia,3036 with probable sarcopenia,and 1926 with sarcopenia.After IPTW adjustment,participants with possible sarcopenia had a 46%increased risk of mortality(HR=1.46,95%CI:1.19-1.77)compared to those without sarcopenia,and participants with sarcopenia had a 99%increased risk(HR=1.99,95%CI:1.43-2.76).Conclusions This research underscores the significant impact of sarcopenia on the mortality risk within the Chinese population,highlighting that sarcopenia can significantly increase the risk of death in adults aged 45 and above.