视网膜色素上皮细胞移植治疗色素性视网膜炎的研究进展

Research progress of retinal pigment epithelial cell transplantation in the treatment of retinitis pigmentosa

色素性视网膜炎(RP)是一种由基因突变导致的光感受器细胞凋亡以及视网膜色素上皮(RPE)细胞萎缩的遗传性疾病,临床表现为夜盲、周边视野缺损及进行性视力下降。RPE细胞凋亡在RP的进展中起着重要作用,外源性植入RPE细胞作为一种替代疗法已经在动物实验及临床试验中显示出了一定的疗效。随着细胞来源的多样化、手术技术的更新以及生物材料的不断出现,为细胞治疗提供了更多的可能与希望。未来进一步推动这一领域的发展,未来仍需加强医学、生物工程学等多个学科之间的合作,共同推动治疗方法的创新与发展,相信在将来RPE细胞移植疗法会展现出更加光明的前景。

Retinitis pigmentosa(RP)is a genetic disorder of photoreceptor cell apoptosis and retinal pigment epithelium(RPE)cell atrophy caused by gene mutation.The clinical manifestations are night blindness,peripheral visual field loss and progressive vision loss.RPE cell apoptosis plays an important role in the progression of RP,and exogenous implantation of RPE cells as an alternative therapy has shown certain efficacy in animal experiments and clinical trials.With the diversification of cell sources,the update of surgical techniques and the continuous emergence of biological materials,more possibilities and hopes are provided for cell therapy.To further promote the development of this field in the future,it is still necessary to strengthen the cooperation between medicine,bioengineering and other disciplines in the future to jointly promote the innovation and development of therapeutic methods.It is believed that RPE cell transplantation therapy will show a brighter prospect in the future.