Inhibition of liver cholesterol synthesis by a diet-induced gut hormone

The liver controls blood cholesterol levels through biosynthesis and recycling of cholesterol^(1).It is a major target for pharmacological interventions of blood cholesterol in the clinical settings,where Statins inhibit cholesterol biosynthesis,and PCSK9 inhibitors enhance recycling of low-density lipoprotein(LDL)from blood into the liver2.A recent Cell paper reports that the liver activity is regulated by a diet-induced gut hormone,Cholesin,in the gut-liver axis for control of cholesterol biosynthesis3.