补骨脂临床肝毒性的研究进展

Research Progress in Clinical Hepatotoxicity of Psoraleae Fructus

补骨脂为豆科植物补骨脂(Psoralea corylifolia L.)的干燥成熟果实,具有温肾助阳、纳气平喘、温脾止泻等作用。但补骨脂也因其肝毒性的副作用,而引起了人们对其用药安全的担忧。该文主要从补骨脂与肝损伤的关系、补骨脂的肝毒性成分、补骨脂的肝毒性特点及其减毒方法等方面进行了综述,以期为补骨脂的安全、合理使用提供参考。

Psoraleae fructus is dried mature fruit of Psoralea corylifolia L.,a plant from the Fabaceae family,and has various therapeutic effects,including warming the kidneys and assisting yang,relieving asthma,warming spleen and stopping diarrhea.However,psoraleae fructus has raised concerns regarding its medication safety due to its hepatotoxic side effects.This article mainly reviews the relationship between psoraleae fructus and liver injury,its hepatotoxic components,hepatotoxic characteristics,and methods to reduce its toxicity,aiming to provide reference for the safe and rational use of psoraleae fructus.