基于文献的盐酸罂粟碱的配伍禁忌与应对策略分析

Analysis of Compatibility and Contraindication of Papaverine Hydrochloride and Coping Strategies Based on Literature

目的:通过文献检索分析盐酸罂粟碱的配伍禁忌情况及其应对策略,为保障临床盐酸罂粟碱的用药安全提供参考。方法:以“罂粟碱“”配伍禁忌“”稳定性”等为关键词,在中国知网、万方数据库、重庆维普等数据库中进行文献检索,采集文献中所列配伍禁忌药物的相关信息,并探究盐酸罂粟碱与配伍禁忌药物合用时的用药安全策略。结果:在数据库中共检索到与盐酸罂粟碱配伍禁忌相关的文献19篇,共涉及11类27种药品,其中20种进行了实验验证;11类药物中,主要的药物种类为消化系统用药(6种)、抗感染药物(5种)、中药注射剂(4种)和心血管系统用药(3种);27种药品与盐酸罂粟碱配伍后均以出现浑浊、絮状物或沉淀为主要特征,其中明确配伍禁忌与pH值相关的药品有16种;针对这27种药品,应避免盐酸罂粟碱与其合用或续接输注,必须续接输注时应选用合适溶媒进行充分冲管。结论:盐酸罂粟碱属于强酸弱碱性药物,其稳定性与溶液的pH值密切相关,将其与其他药物配伍或续接使用时,务必注意药物的酸碱度,以避免配伍禁忌不良事件的发生,从而保证患者的用药安全。

Objective:To analyze the compatibility and contraindication of papaverine hydrochloride and coping strategies through literature retrieval,and provide reference for clinical safe use of papaverine hydrochloride.Methods:A literature retrieval was conducted using keywords such as"papaverine","compatibility and contraindication","stability"in databases such as CNKI,Wanfang Data,and Chongqing VIP.Relevant information on drugs with compatibility and contraindication was collected from the literature,and safe medication strategies for using papaverine hydrochloride with these drugs were explored.Results:A total of 19 articles related to the compatibility and contraindication of papaverine hydrochloride were found in databases,involving 11 categories of 27 drugs,20 of which had been experimentally validated.Among 11 categories,the main drug types were digestive system drugs(6),anti-infective drugs(5),traditional Chinese medicine injections(4),and cardiovascular system drugs(3).After combining papaverine hydrochloride with 27 drugs,the primary feature was appearance of turbidity,flocculent substances or precipitation.Of these,16 drugs were clearly associated with compatibility and contraindication issues related to pH.For these 27 drugs,it is recommended to avoid co-administration or sequential infusion with papaverine hydrochloride.If sequential infusion is necessary,appropriate solvents should be selected for thorough flushing.Conclusion:Papaverine hydrochloride is a weakly alkaline drug with strong acidic properties,and its stability is closely related to pH of the solution.When combining it with other drugs or performing sequential infusion,it is essential to consider pH of drugs to avoid any adverse event associated with compatibility and contraindication,so as to ensure the medication safety of patients.