肠道菌群在器官缺血再灌注损伤中的作用及机制研究进展

Progress in research on the role and mechanism of gut microbiota in organ ischemia reperfusion injury

缺血再灌注损伤(IRI)是指在组织或器官缺血一段时间后,血流恢复时造成的损伤。 在临床实践中,器官移植不可避免地会发生IRI,其发生机制复杂,仍缺乏有效治疗手段。 肠道菌群通过调控免疫反应、炎症响应以及代谢产物的生成参与多系统疾病的发生发展过程,亦在多器官IRI 过程表现出深远影响。 本文综述近期关于肠道菌群及其代谢产物在肠道及肝脏、肾脏等器官IRI 中的作用和机制研究进展,以期为器官IRI 的诊疗提供新的思路。

Ischemia reperfusion injury(IRI)refers to the damage caused when blood flow is restored to tissues or organs after a period of ischemia.In clinical practice,IRI is an inevitable occurrence during organ transplantation.The mechanisms underlying IRI are complex,and effective treatment options are still lacking.The intestinal flora plays a significant role in the development of multisystem diseases by regulating immune responses,inflammatory reactions,and the production of metabolic byproducts.It also exerts a profound impact on the IRI process in multiple organs.This article reviews recent progress in research on the roles and mechanisms of the intestinal flora and its metabolic products in IRI of the intestines,liver,kidneys,and other organs,with the hope of providing new diagnostic and therapeutic strategies for IRI.