摘要
In their recent paper published in Nature Cell Biology,1 Wang and colleagues defined a pathogenetic mechanism among a variety of lysosomal storage disorders(LSDs)mediating neuronal death and disease progression.The authors observed neuron-intrinsic activated cGAS-STING signaling triggered by accumulating cytosolic dsDNA,and thus,they provide a valuable target for directed therapies.
基金
supported by the Sobek Foundation
the Faber Foundation
the Ernst-Jung Foundation
the DFG(SFB 992,SFB1160,SFB 1479,SFB/TRR167,Reinhart-Koselleck-Grant,Gottfried Wilhelm Leibniz-Prize,Novo-Nordisk Prize)
the Ministry of Science,Research and Arts,Baden-Wuerttemberg(Sonderlinie“Neuroinflammation”).
