半个多世纪的“金标准”:复方左旋多巴治疗帕金森病

The“gold standard”for more than half a century:compound levodopa in the treatment of Parkinson′s disease

药物治疗依然是帕金森病患者获得生活质量长久改善的基本保证。自20世纪60年代复方左旋多巴开始用于治疗帕金森病起,即被证明是治疗帕金森病最有效的药物,不仅可以改善患者运动症状,还可以提高生活质量。然而,临床上关于复方左旋多巴的使用仍然存在一些误区,伴随着疾病的进展,其治疗产生的相关运动并发症对临床医生和患者造成了一定困扰。文中对近年来帕金森病领域国内外临床研究成果以及指南、共识进行评述,同时结合我国国情及临床实践,对复方左旋多巴的药理学特点、循证研究证据、临床规范使用等进行全面、系统的分析,希望能规范复方左旋多巴在临床的合理应用,为广大临床工作者提供用药参考。

Today,medication remains a fundamental guarantee of long-term improvement in the quality of life for patients with Parkinson′s disease(PD).Since the 1960s,compound levodopa has been used to treat PD,and has been proved to be the most effective drug for the treatment of PD,which can not only improve the motor symptoms of PD patients,but also improve the quality of life.However,there are still some misunderstandings about the use of compound levodopa in clinical practice.With the progression of the disease,the related motor complications caused by its treatment have caused certain troubles to both clinicians and patients.This paper reviewed the results of related clinical studies at home and abroad,as well as guidelines and consensus,and carried out a comprehensive and systematic analysis and summary of the pharmacological characteristics of compound levodopa,evidence-based research evidence,clinical standard use,etc,combined with China′s national conditions and clinical practice,hoping to standardize the reasonable clinical application of compound levodopa and provide drug reference for the majority of clinical workers.