多系统萎缩患者体位性低血压的危险因素分析

Analysis of risk factors of orthostatic hypotension in patients with multiple system atrophy

目的探讨多系统萎缩(MSA)患者体位性低血压(OH)的危险因素。方法共纳入199例MSA患者,根据OH的严重程度将患者分组,比较各组间临床资料的差异,并用有序Logistic回归分析MSA患者出现OH的危险因素。结果不同OH等级患者在性别、糖尿病病史、疾病等级、晕厥、卧位高血压、疲劳、脑保护药物方面,差异有统计学意义(均P<0.05)。有序Logistic回归分析发现,疾病等级(很可能的MSA)、晕厥、卧位高血压、疲劳是MSA患者发生OH的独立危险因素(均P<0.05)。结论OH在MSA患者中普遍存在,其严重程度受多方面影响。其中疾病等级(很可能的MSA)、晕厥、卧位高血压、疲劳是MSA伴发OH的独立危险因素。

Objective To explore the risk factors of orthostatic hypotension(OH)in patients with multiple system atrophy(MSA).Methods A total of 199 MSA patients were included,and they were divided into groups based on the severity of OH.The data differences between the groups were compared,and the risk factors for the occurrence of OH in MSA patients were analyzed from ordered Logistic regression.Results There were significant differences in gender,diabetes,disease grade,syncope,supine hypertension,fatigue and brain protective drugs among patients with different OH grades(all P<0.05).Ordered Logistic regression analysis found that disease grade(probable MSA),syncope,supine hypertension,and fatigue were independent risk factors for the occurrence of OH in MSA patients(all P<0.05).Conclusions OH is commonly present in MSA patients,and its severity is influenced by many factors.Disease grade(probable MSA),syncope,lying hypertension and fatigue are independent risk factors of OH in patients with MSA.