支架联合抽吸取栓治疗高龄前循环急性大血管闭塞性脑卒中的疗效

Efficacy of stenting combined suction embolization in treating elderly acute large vascular occlusion stroke in anterior circulation

目的探讨支架联合抽吸取栓治疗高龄前循环急性大血管闭塞性脑卒中(ALVOS)的疗效。方法选取本院2020年1月至2020年12月收治的接受单纯支架取栓治疗的ALVOS患者60例(对照组)和2021年1月至2022年12月收治的接受支架联合抽吸取栓治疗的ALVOS患者60例(观察组)进行对照研究。对两组治疗前后的临床资料进行比较分析。结果观察组的总血管复通率明显高于对照组(P<0.05)。观察组治疗后单核细胞趋化蛋白、IL-6、TNF-α、神经元特异性烯醇化酶、中枢神经特异性蛋白及NIHSS、mRS评分下降程度较对照组更显著(均P<0.05)。观察组总有效率明显高于对照组(P<0.05)。结论与单纯支架取栓相比支架联合抽吸取栓治疗能有效提高高龄ALVOS患者血管复通率,调节炎性细胞因子和神经功能预后相关因子,对神经功能恢复和炎症反应有较好的调控作用,可改善患者预后。

Objective To investigate the efficacy of stenting combined suction embolization in treating elderly acute large vascular occlusion stroke(ALVOS)in anterior circulation.Methods Sixty ALVOS patients who received stent thrombectomy alone from January 2020 to December 2020(control group)and 60 ALVOS patients who received stenting combined suction embolization from January 2021 to December 2022(observation group)were compared.The clinical data of the two groups before and after treatment were compared and analyzed.Results The total vascularization rate of the observation group was significantly higher than the control group(P<0.05).The decrease of monocyte chemoattractant protein,IL-6,TNF-α,neuron-specific enolase,central nerve specific protein and NIHSS and mRS scores after treatment in the observation group were more significantly than those in the control group(all P<0.05).The total effective rate in the observation group was significantly higher than that in the control group(P<0.05).Conclusion Compared with stent thrombectomy alone,stent combined with thrombectomy can effectively improve the vascular revascularization rate in elderly patients with ALVOS,regulate the expression levels of inflammatory cytokines and neurological function prognosis-related factors,and have a better regulation effect on nerve function recovery and inflammatory response,and improve the prognosis of patients.