多杀性巴氏杆菌的摄铁机制研究进展

Research Progress on Iron Uptake Mechanism of Pasteurella multocida

多杀性巴氏杆菌可广泛感染多种动物,引起出血性败血症或传染性肺炎。铁是多杀性巴氏杆菌感染宿主过程中生长、定植和增殖必不可少的营养物质,竞争宿主铁离子是该病原体感染致病的关键环节。近年来,多杀性巴氏杆菌的摄铁系统及其发生与调控机制方面的研究取得了一系列重要进展。本文系统阐述了多杀性巴氏杆菌的转铁蛋白受体摄铁机制、血红素受体摄铁机制、铁载体摄铁机制及其摄铁系统的表达与调控机制,以期为多杀性巴氏杆菌摄铁系统的分子致病机理研究提供系统的理论知识,为多杀性巴氏杆菌分子靶标药物及亚单位疫苗的研发提供新思路。

Pasteurella multocida(P.multocida)can infect a wide range of animals,causing hemorrhagic septicemia or infectious pneumonia.Iron is an essential nutrient for growth,colonization,and proliferation of P.multocida during infection of the host,and competition for iron ions in the host is a critical link in the pathogenesis of this pathogen.In recent years,a series of significant research advances have progressed in the iron uptake system of P.multocida,as well as its occurrence and regulatory mechanisms.The mechanisms of iron uptake by transferrin,heme receptors and siderophore,and the mechanism of expression and regulation of the P.multocida iron uptake system are all described in this paper.Aiming to provide systematic theoretical knowledge for the study of the molecular pathogenesis of the P.multocida iron uptake system and to spark new ideas for the investigation and development of molecular target drugs and subunit vaccines of P.multocida.