脊髓损伤后微环境中免疫反应的文献计量分析

Immune responses in the microenvironment after spinal cord injury:a bibliometric analysis

目的分析脊髓损伤后微环境中免疫反应领域的研究现状、热点和发展趋势。方法在中国知网和Web of Science核心合集,检索自建库起至2024年3月期间脊髓损伤后微环境中免疫反应相关研究的文献,采用VOSviewer和CiteSpace对纳入文献的作者、国家、机构、期刊、共被引文献和关键词进行可视化分析并绘制知识图谱。结果共纳入152篇中文文献和455篇英文文献。中、英文发文量逐年增加,中国和美国是该领域的主要研究国家。中文文献中,朱悦是高产作者,中国医科大学是高产机构。英文文献中,Phillip Popovich是高产且高被引作者,俄亥俄州立大学是高产机构。Journal of Neuroscience和Experimental Neurology是重要期刊。中英文研究热点集中在免疫激活、炎症反应和功能恢复等,干细胞移植、巨噬细胞和中医药等在脊髓损伤后免疫反应调控中的研究占比较大。结论微环境中的免疫反应已经成为脊髓损伤领域关注的焦点,研究重点正从免疫机制转向免疫调控策略的探索,一些前沿技术在这方面展现出巨大潜力。未来需加强跨地域、跨机构合作,促进信息共享,加速研究进展和临床转化,以提升患者康复效果。

Objective To analyze the current status,research hotspots and development trends in the field of immune responses inthe microenvironment after spinal cord injury(SCI).Methods Literatrues about immune responses in the microenvironment after SCI were searched from CNKI and the Webof Science Core Collection,from inception to March,2024.VOSviewer and CiteSpace were used to conduct a visualanalysis of authors,countries,institutions,journals,co-cited references and keywords.Results A total of 152 Chinese and 455 English studies were included.The number of publications increased annually,and China and the United States were leading research efforts in this field.In the Chinese literature,Zhu Yue wasthe most prolific author,and China Medical University was the leading institution.In the English literature,Phil‐lip Popovich was the most prolific and highly cited author,and Ohio State University was the leading institution.Journal of Neuroscience and Experimental Neurology were identified as key journals.The research hotspots inboth languages focused on immune activation,inflammatory response and functional recovery.Researches onstem cell transplantation,macrophage and traditional Chinese medicine were particularly prominent in the regulationof immune responses after SCI.Conclusion Immune responses in the microenvironment have emerged as a central focus in SCI research.The emphasisof current researches is shifting from mechanistic exploration to the investigation of immunomodulatory strategies,with several cutting-edge technologies showing significant potential in this regard.Moving forward,increasingcollaboration across regions and institutions are essential to promote information sharing,accelerate scientificprogress,and facilitate clinical translation,ultimately enhance patient rehabilitation outcomes.